Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa

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dc.contributor.authorDe Sousa, Fernando Augusto Cervantes Garcia
dc.contributor.authorParadella, Thaís Cachuté
dc.contributor.authorBrandão, Adriana Aigotti Haberbeck [UNESP]
dc.contributor.authorRosa, Luiz Eduardo Blunter [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionJardim Esplanada II
dc.contributor.institutionCAPES
dc.date.accessioned2022-04-28T20:52:54Z
dc.date.available2022-04-28T20:52:54Z
dc.date.issued2009-01-01
dc.description.abstractCurrently, much is discussed regarding the pre-malignant nature of mouth mucosa lichen planus. Aim: The present study aims at analyzing the alterations found in the epithelial cells present in the oral cavity lichen planus, comparing them to those found in epidermoid carcinoma. Materials and Methods: Histological cross-sections of oral lichen planus and epidermoid carcinoma, dyed by hematoxylineosin, were analyzed through light microscopy. Result: the most frequently found alterations in oral lichen planus were: an increase in the nucleus/cytoplasm relation (93-33%), nucleus membrane thickness (86.67%) and bi-nucleus or multinucleous (86.67%). The Student t test (alpha=5%) revealed a statistically significant difference between the average number of cell alterations in oral lichen planus (5.87±1.57) and in epidermoid carcinoma (7.60±1.81). As to fhe types of alterations, the chi-squared test also revealed statistically significant differences among the lesions assessed in relation to the following cell alterations: nuclear excess chromatism, atypical mitoses, cellular pleomorphism and abnormal cell differentiation (p<0.05). Conclusion: Despite the fact that in some cases, some padiologists may make mistakes in the histopathological diagnosis of oral lichen planus, the results obtained in this study show that the alterations present in oral lichen planus differ considerably from those seen in epidermoid carcinoma, thus showing how distinct these two diseases are.en
dc.description.affiliationDepartment of General Pathology FOSJC UNESP
dc.description.affiliationDepartment of Oral Pathology FOSJC UNESP
dc.description.affiliationJardim Esplanada II, Rua Irmã Maria Demétria Kfruri 196, 12242-500 Sao Jose dos Campos Sao Paulo SP
dc.description.affiliationCAPES
dc.description.affiliationUnespDepartment of General Pathology FOSJC UNESP
dc.description.affiliationUnespDepartment of Oral Pathology FOSJC UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent245-248
dc.identifierhttp://dx.doi.org/10.1016/S1808-8694(15)30785-0
dc.identifier.citationBrazilian Journal of Otorhinolaryngology, v. 75, n. 2, p. 245-248, 2009.
dc.identifier.doi10.1016/S1808-8694(15)30785-0
dc.identifier.issn1808-8686
dc.identifier.issn1808-8694
dc.identifier.scopus2-s2.0-67549140236
dc.identifier.urihttp://hdl.handle.net/11449/225508
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.sourceScopus
dc.subjectEpidermoid carcinoma
dc.subjectLichen planus
dc.subjectMouth mucosa
dc.titleComparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosaen
dc.typeArtigo

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