Leptospira reservoirs among wildlife in Brazil: Beyond rodents

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dc.contributor.authorFornazari, Felipe [UNESP]
dc.contributor.authorLangoni, Helio [UNESP]
dc.contributor.authorMarson, Pâmela Merlo [UNESP]
dc.contributor.authorNóbrega, Diego Borin
dc.contributor.authorTeixeira, Carlos Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSão Paulo Research Foundation scholarship (FAPESP 2012/02927-1)
dc.contributor.institutionScientific Scholarship of the National Council for Scientific and Technological Development (CNPq) Pâmela Merlo Marsond
dc.contributor.institutionUniversity of Calgary
dc.date.accessioned2018-12-11T17:16:35Z
dc.date.available2018-12-11T17:16:35Z
dc.date.issued2018-02-01
dc.description.abstractLeptospirosis is a disease of great importance in tropical regions. Infection occurs mainly through contact with water contaminated with the urine of infected animals, especially that of rodents. Despite the diversity and abundance of wild fauna in Brazil, little is known about the role of other wild species in the epidemiology of leptospirosis. This study aimed to investigate new reservoirs of Leptospira among wildlife in Brazil, using serological and molecular diagnoses in a large-sized sample. Biological samples were collected from 309 free-ranging mammals, belonging to 16 species. The majority of the animals included were opossums (Didelphis albiventris) and coatis (Nasua nasua). Blood and urine samples were subjected to the microscopic agglutination test (MAT) and real-time PCR, respectively. Genetic characterization of genomospecies was performed using PCR amplicons. Statistical analysis was applied to test associations between positive diagnoses and age, sex, season and type of environment. The prevalence of infection found via MAT and PCR was 11% and 5.5%, respectively. If these tests are taken to be complementary, the overall prevalence was 16%. The most common serogroups were Djasiman and Australis, while L. santarosai was the prevalent genomospecies. Significant differences in prevalence between animal species were observed. Greater risk of infection was detected among adult opossums than among young ones. The influence of each serogroup and genomospecies was tested for the same variables, and this revealed higher risk of infection by L. santarosai among male opossums than among females. The present study highlights the exposure and carrier status of several wild species in Brazil and it indicates that coatis and other carnivores are priorities for further investigations.en
dc.description.affiliationDepartment of Veterinary Hygiene and Public Health (DHVSP) School of Veterinary Medicine and Animal Science (FMVZ) São Paulo State University (UNESP), Rubião Jr. 18618-681
dc.description.affiliationSão Paulo Research Foundation scholarship (FAPESP 2012/02927-1)
dc.description.affiliationScientific Scholarship of the National Council for Scientific and Technological Development (CNPq) Pâmela Merlo Marsond
dc.description.affiliationInstitute of Biotechnology (IBTEC) São Paulo State University (UNESP), Rubião Jr. 18607-440
dc.description.affiliationDepartment of Production Animal Health Faculty of Veterinary Medicine University of Calgary
dc.description.affiliationCenter for Medicine and Wildlife Research (CEMPAS) School of Veterinary Medicine and Animal Science (FMVZ) São Paulo State University (UNESP), Rubião Jr. 18618-681
dc.description.affiliationUnespDepartment of Veterinary Hygiene and Public Health (DHVSP) School of Veterinary Medicine and Animal Science (FMVZ) São Paulo State University (UNESP), Rubião Jr. 18618-681
dc.description.affiliationUnespInstitute of Biotechnology (IBTEC) São Paulo State University (UNESP), Rubião Jr. 18607-440
dc.description.affiliationUnespCenter for Medicine and Wildlife Research (CEMPAS) School of Veterinary Medicine and Animal Science (FMVZ) São Paulo State University (UNESP), Rubião Jr. 18618-681
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent205-212
dc.identifierhttp://dx.doi.org/10.1016/j.actatropica.2017.11.019
dc.identifier.citationActa Tropica, v. 178, p. 205-212.
dc.identifier.doi10.1016/j.actatropica.2017.11.019
dc.identifier.file2-s2.0-85036592809.pdf
dc.identifier.issn1873-6254
dc.identifier.issn0001-706X
dc.identifier.scopus2-s2.0-85036592809
dc.identifier.urihttp://hdl.handle.net/11449/175591
dc.language.isoeng
dc.relation.ispartofActa Tropica
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCoati
dc.subjectEpidemiology
dc.subjectLeptospirosis
dc.subjectOpossum
dc.subjectZoonosis
dc.titleLeptospira reservoirs among wildlife in Brazil: Beyond rodentsen
dc.typeArtigo
unesp.author.lattes8560913137958850[5]
unesp.author.orcid0000-0001-6639-037X[5]

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