Omega-3 Fatty Acids Reduce Inflammation in Rat Apical Periodontitis

dc.contributor.authorAzuma, Mariane Maffei [UNESP]
dc.contributor.authorGomes-Filho, João Eduardo [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorCardoso, Carolina de Barros Moraes [UNESP]
dc.contributor.authorPipa, Camila Barbosa [UNESP]
dc.contributor.authorKawai, Toshihisa
dc.contributor.authorConti, Leticia Citelli [UNESP]
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNOVA Southeastern University College of Dental Medicine
dc.contributor.institutionUniversity of Michigan
dc.date.accessioned2018-12-11T17:17:50Z
dc.date.available2018-12-11T17:17:50Z
dc.date.issued2018-04-01
dc.description.abstractIntroduction: The effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on pro- and anti-inflammatory mediators were evaluated in a rat model of pulp exposure–induced apical periodontitis (AP). Methods: Twenty-eight male Wistar rats were divided into 4 groups: control, untreated rats (group C); control rats treated with ω-3 PUFAs (group C-O); rats with pulp exposure–induced AP (group AP); and rats with pulp exposure–induced AP treated with ω-3 PUFAs (group AP-O). Omega-3 PUFAs were administered orally once a day for 15 days before pulp exposure; this treatment was continued for 30 days after pulp exposure. The rats were sacrificed 30 days after pulp exposure, and their dissected jaws were subjected to immunohistochemical analysis to detect immunoreactivity for tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-1β, IL-17, and IL-10 on the periapical bone surface. The results were statistically evaluated using analysis of variance and the Tukey post-test. The significance level was set at 5%. Results: Immunoreactivity for the proinflammatory cytokines TNF-α, IL-6, IL-1β, and IL-17 was higher in the AP group than in the AP-O, C, and C-O groups (P <.05). Immunoreactivity for the anti-inflammatory cytokine IL-10 was lower in the AP group than in the AP-O group (P <.05). Conclusions: Supplementation with ω-3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of TNF-α, IL-6, IL-1β, and IL-17 but increasing levels of IL-10.en
dc.description.affiliationDepartment of Endodontics Araçatuba Dental School Universidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Basic Sciences Araçatuba Dental School Universidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Periodontology NOVA Southeastern University College of Dental Medicine
dc.description.affiliationDepartment of Cariology Restorative Sciences and Endodontics University of Michigan
dc.description.affiliationUnespDepartment of Endodontics Araçatuba Dental School Universidade Estadual Paulista (UNESP)
dc.description.affiliationUnespDepartment of Basic Sciences Araçatuba Dental School Universidade Estadual Paulista (UNESP)
dc.format.extent604-608
dc.identifierhttp://dx.doi.org/10.1016/j.joen.2017.12.008
dc.identifier.citationJournal of Endodontics, v. 44, n. 4, p. 604-608, 2018.
dc.identifier.doi10.1016/j.joen.2017.12.008
dc.identifier.file2-s2.0-85041633352.pdf
dc.identifier.issn0099-2399
dc.identifier.lattes4408095517346846
dc.identifier.lattes9235743081667362
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-85041633352
dc.identifier.urihttp://hdl.handle.net/11449/175845
dc.language.isoeng
dc.relation.ispartofJournal of Endodontics
dc.relation.ispartofsjr1,585
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectApical periodontitis
dc.subjectcytokine, endodontic infection
dc.subjectomega-3 fatty acid
dc.titleOmega-3 Fatty Acids Reduce Inflammation in Rat Apical Periodontitisen
dc.typeArtigo
unesp.author.lattes4408095517346846[3]
unesp.author.lattes9235743081667362
unesp.author.orcid0000-0003-4859-0583[3]

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