Absence of mutagenicity of plants used to treat gastrointestinal disorders

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dc.contributor.authorSantos, F. V.
dc.contributor.authorAndreo, M. [UNESP]
dc.contributor.authorNasser, A. L M [UNESP]
dc.contributor.authorMoreira, L. M.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorCólus, I. M S
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-27T11:28:21Z
dc.date.available2014-05-27T11:28:21Z
dc.date.issued2013-02-06
dc.description.abstractThe Brazilian Savanna (locally called Cerrado) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with compounds obtained from different species have shown the risks of DNA damage. The present work assessed the in vivo mutagenicity of three plant species used in popular medicine to treat human gastrointestinal disorders (Mouriri pusa, Qualea grandiflora and Qualea multiflora). The micronucleus assay was performed in peripheral blood of mice submitted to acute treatments. Results showed that no assessed extracts were mutagenic in vivo. In fact, the absence of mutagenicity in the present study indicates that the extracts do not contain compounds capable of inducing DNA breaks or chromosomal loss. However, further analysis should be performed in others systems to guarantee their safety, mainly to human chronic use.en
dc.description.affiliationUniversidade Federal de São João Del Rei (UFSJ) Campus Centro-Oeste, Divinópolis, MG
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Instituto de Química, Araraquara, SP
dc.description.affiliationUniversidade Federal de São João Del Rei (UFSJ) Campus Dom Bosco Departamento de Engenharia de Biossistemas, São João Del Rei, MG
dc.description.affiliationUniversidade Estadual de Londrina (UEL) Departamento de Biologia Geral, Londrina, PR
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Araraquara, SP
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Instituto de Química, Araraquara, SP
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Araraquara, SP
dc.format.extent191-195
dc.identifierhttp://dx.doi.org/10.2298/ABS1301191S
dc.identifier.citationArchives of Biological Sciences, v. 65, n. 1, p. 191-195, 2013.
dc.identifier.doi10.2298/ABS1301191S
dc.identifier.file2-s2.0-84873189537.pdf
dc.identifier.issn0354-4664
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scopus2-s2.0-84873189537
dc.identifier.urihttp://hdl.handle.net/11449/74564
dc.identifier.wosWOS:000312046300023
dc.language.isoeng
dc.relation.ispartofArchives of Biological Sciences
dc.relation.ispartofjcr0.648
dc.relation.ispartofsjr0,232
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBrazilian savanna
dc.subjectDNA damage
dc.subjectMedicinal plants
dc.subjectMicronucleus assay
dc.subjectMutagenicity
dc.titleAbsence of mutagenicity of plants used to treat gastrointestinal disordersen
dc.typeArtigo
dcterms.licensehttp://www.doiserbia.nb.rs/OpenAccess.aspx
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0003-3032-2556[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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Artigos - Ciências Biológicas - São Vicente
Araraquara - FCF - Faculdade de Ciências Farmacêuticas