Methods of Analysis for Peritubular Capillaritis and Glomerulitis in Acute Renal Rejection: Capillaritis in Management of Routine Diagnosis

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dc.contributor.authorDos Santos, D. C. [UNESP]
dc.contributor.authorAndrade, Luís Gustavo Modelli de [UNESP]
dc.contributor.authorDe Carvalho, M. F. C. [UNESP]
dc.contributor.authorMoraes Neto, F. A.
dc.contributor.authorViero, Rosa Marlene [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAmaral Carvalho Hosp
dc.date.accessioned2014-12-03T13:10:36Z
dc.date.available2014-12-03T13:10:36Z
dc.date.issued2014-01-01
dc.description.abstractGlomerulitis and peritubular capillaritis have been recognized as important lesions in acute renal rejection (AR). We studied glomerulitis and peritubular capillaritis in AR by 2 methods and investigated associations with C4d, type/grade of AR, and allograft survival time. Glomerulitis was measured according to Banff scores (glomerulitis by Banff Method [gBM]) and by counting the number of intraglomerular inflammatory cells (glomerulitis by Quantitative Method [gQM]). Capillaritis was classified by the Banff scoring system (peritubular capillaritis by Banff Method [ptcBM]) and by counting the number of cells in peritubular capillaries in 10 high-power fields (hpf; peritubular capillaritis by Quantitative Method [ptcQM]). These quantitative analyses were performed in an attempt to improve our understanding of the role played by glomerulitis and capillaritis in AR. The g0 + g1 group (gBM) associated with negative C4d (P = .02). In peritubular capillaritis, a larger number of cells per 10 hpf in peritubular capillaries (ptcQM) were observed in positive C4d cases (P = .03). The group g2 + g3 (gBM) correlated with graft loss (P = .01). Peritubular capillaritis was not significantly related to graft survival time. Our study showed that the Banff scoring system is the best method to study glomerulitis and observed that the evaluation of capillaritis in routine biopsies is difficult and additional studies are required for a better understanding of its meaning in AR biopsy specimens of renal allografts.en
dc.description.affiliationUniv Estadual Paulista, Botucatu Sch Med, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Sch Med, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationAmaral Carvalho Hosp, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Sch Med, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Sch Med, Dept Internal Med, Botucatu, SP, Brazil
dc.format.extent87-93
dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2013.04.016
dc.identifier.citationTransplantation Proceedings. New York: Elsevier Science Inc, v. 46, n. 1, p. 87-93, 2014.
dc.identifier.doi10.1016/j.transproceed.2013.04.016
dc.identifier.issn0041-1345
dc.identifier.lattes1453564171333848
dc.identifier.urihttp://hdl.handle.net/11449/112309
dc.identifier.wosWOS:000331596900015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransplantation Proceedings
dc.relation.ispartofjcr0.806
dc.relation.ispartofsjr0,422
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleMethods of Analysis for Peritubular Capillaritis and Glomerulitis in Acute Renal Rejection: Capillaritis in Management of Routine Diagnosisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1453564171333848
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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