Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity

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dc.contributor.authorMininel, Francisco Jose [UNESP]
dc.contributor.authorLeonardo Junior, Carlos Sergio [UNESP]
dc.contributor.authorEspanha, Livia Greghi [UNESP]
dc.contributor.authorResende, Flavia Aparecida [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.authorFujimura Leite, Clarice Queico [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorSantos, Lourdes Campaner dos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:29Z
dc.date.available2014-12-03T13:11:29Z
dc.date.issued2014-01-01
dc.description.abstractTerminalia is a genus of Combretaceous plants widely distributed in tropical and subtropical regions. Thus, the aim of this study was to quantify the majority compounds of the hydroalcoholic extract (7 : 3, v/v) of the leaves from T. catappa by HPLC-PDA, chemically characterize by hyphenated techniques (HPLC-ESI-IT-MSn) and NMR, and evaluate its mutagenic activity by the Salmonella/microsome assay on S. typhimurium strains TA98, TA97a, TA100, and TA102. The quantification of analytes was performed using an external calibration standard. Punicalagin is themost abundant polyphenol found in the leaves. The presence of this compound as a mixture of anomers was confirmed using HPLC-PDA and H-1 and C-13 NMR. Mutagenic activity was observed in strains TA100 and TA97a. As the extract is a complex mixture of punicalagin, its derivatives, and several other compounds, the observed mutagenicity may be explained in part by possible synergistic interaction between the compounds present in the extract. These studies show that mutagenic activity of T. catappa in the Ames test can only be observed when measured at high concentrations. However, considering the mutagenic effects observed for T. catappa, this plant should be used cautiously for medicinal purposes.en
dc.description.affiliationSao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, BR-11350000 Sao Vicente, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, BR-11350000 Sao Vicente, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 09/52237-9
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.1155/2014/676902
dc.identifier.citationEvidence-based Complementary And Alternative Medicine. New York: Hindawi Publishing Corporation, 11 p., 2014.
dc.identifier.doi10.1155/2014/676902
dc.identifier.fileWOS000333351000001.pdf
dc.identifier.fileWOS000333351000001.epub
dc.identifier.issn1741-427X
dc.identifier.lattes7927877224326837
dc.identifier.lattes3538253640602977
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/113196
dc.identifier.wosWOS:000333351000001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofjcr2.064
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleCharacterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activityen
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes7927877224326837
unesp.author.lattes3538253640602977
unesp.author.orcid0000-0003-3032-2556[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Química Orgânica - IQ
Artigos - Ciências Biológicas - FCFAR
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