Bone healing in surgically created defects treated with either bioactive glass particles, a calcium sulfate barrier, or a combination of both materials: A histological and histometric study in rat tibias
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Melo, Luiz G. N. [UNESP]
Nagata, Maria José Hitomi [UNESP]
Bosco, Álvaro Francisco [UNESP]
Ribeiro, Luciana L. G. [UNESP]
Leite, Cristiane M. [UNESP]
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Objective: The purpose of this study was to histologically analyze the influence of bioactive glass and/or a calcium sulfate barrier on bone healing in surgically created defects in rat tibias. Material and methods: Sixty-four rats were divided into 4 groups: C (control), CS (calcium sulfate), BG (bioactive glass), and BG/CS (bioactive glass/calcium sulfate). A surgical defect was created in the tibia of each animal. In Group CS, a calcium sulfate barrier was placed to cover the defect. In Group BG the defect was filled with bioactive glass. In Group BG/CS, it was filled with bioactive glass and protected by a barrier of calcium sulfate. Animals were sacrificed at 10 or 30 days post-operative. The formation of new bone in the cortical area of the defect was evaluated histomorphometrically. Results: At 10 days post-operative, Group C presented significantly more bone formation than Groups CS, BG, or BG/CS. No statistically significant differences were found between the experimental groups. At 30 days post-operative, Group C demonstrated significantly more bone formation than the experimental groups. Groups CS and BG/CS showed significantly more bone formation than Group BG. No statistically significant differences were found between Group CS and BG/CS. Conclusions: (a) the control groups had significantly more bone formation than the experimental groups; (b) at 10 days post-operative, no significant differences were found between any of the experimental groups; and (c) at 30 days post-operative, the groups with a calcium sulfate barrier had significantly more bone formation than the group that used bioactive glass only. Copyright © Blackwell Munksgaard 2005.
Bioactive, Bone regeneration, Bone substitutes, Calcium sulfate, Glass, bioglass, calcium sulfate, animal, artificial membrane, bone prosthesis, bone regeneration, ceramics, comparative study, drug effect, image processing, male, methodology, periodontics, physiology, rat, tibia, Animals, Bone Regeneration, Bone Substitutes, Calcium Sulfate, Ceramics, Guided Tissue Regeneration, Periodontal, Image Processing, Computer-Assisted, Male, Membranes, Artificial, Rats, Tibia
Clinical Oral Implants Research, v. 16, n. 6, p. 683-691, 2005.