Bone healing in surgically created defects treated with either bioactive glass particles, a calcium sulfate barrier, or a combination of both materials: A histological and histometric study in rat tibias

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dc.contributor.authorMelo, Luiz G. N. [UNESP]
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorRibeiro, Luciana L. G. [UNESP]
dc.contributor.authorLeite, Cristiane M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:42Z
dc.date.available2014-05-27T11:21:42Z
dc.date.issued2005-12-01
dc.description.abstractObjective: The purpose of this study was to histologically analyze the influence of bioactive glass and/or a calcium sulfate barrier on bone healing in surgically created defects in rat tibias. Material and methods: Sixty-four rats were divided into 4 groups: C (control), CS (calcium sulfate), BG (bioactive glass), and BG/CS (bioactive glass/calcium sulfate). A surgical defect was created in the tibia of each animal. In Group CS, a calcium sulfate barrier was placed to cover the defect. In Group BG the defect was filled with bioactive glass. In Group BG/CS, it was filled with bioactive glass and protected by a barrier of calcium sulfate. Animals were sacrificed at 10 or 30 days post-operative. The formation of new bone in the cortical area of the defect was evaluated histomorphometrically. Results: At 10 days post-operative, Group C presented significantly more bone formation than Groups CS, BG, or BG/CS. No statistically significant differences were found between the experimental groups. At 30 days post-operative, Group C demonstrated significantly more bone formation than the experimental groups. Groups CS and BG/CS showed significantly more bone formation than Group BG. No statistically significant differences were found between Group CS and BG/CS. Conclusions: (a) the control groups had significantly more bone formation than the experimental groups; (b) at 10 days post-operative, no significant differences were found between any of the experimental groups; and (c) at 30 days post-operative, the groups with a calcium sulfate barrier had significantly more bone formation than the group that used bioactive glass only. Copyright © Blackwell Munksgaard 2005.en
dc.description.affiliationDepartment of Surgery and Integrated Clinic Dental School of Araçatuba University of State of São Paulo 'Júlio de Mesquita Filho' - UNESP, Araçatuba
dc.description.affiliation, Rua Afonso Pena 325 - Apt. 51, CEP: 16010-370 - Aracatuba, SP
dc.description.affiliationUnespDepartment of Surgery and Integrated Clinic Dental School of Araçatuba University of State of São Paulo 'Júlio de Mesquita Filho' - UNESP, Araçatuba
dc.format.extent683-691
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0501.2005.01090.x
dc.identifier.citationClinical Oral Implants Research, v. 16, n. 6, p. 683-691, 2005.
dc.identifier.doi10.1111/j.1600-0501.2005.01090.x
dc.identifier.issn0905-7161
dc.identifier.issn1600-0501
dc.identifier.lattes8399870097572073
dc.identifier.lattes9831236034935598
dc.identifier.scopus2-s2.0-33644697375
dc.identifier.urihttp://hdl.handle.net/11449/68548
dc.identifier.wosWOS:000233290200008
dc.language.isoeng
dc.relation.ispartofClinical Oral Implants Research
dc.relation.ispartofjcr4.305
dc.relation.ispartofsjr2,462
dc.relation.ispartofsjr2,462
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBioactive
dc.subjectBone regeneration
dc.subjectBone substitutes
dc.subjectCalcium sulfate
dc.subjectGlass
dc.subjectbioglass
dc.subjectcalcium sulfate
dc.subjectanimal
dc.subjectartificial membrane
dc.subjectbone prosthesis
dc.subjectbone regeneration
dc.subjectceramics
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectimage processing
dc.subjectmale
dc.subjectmethodology
dc.subjectperiodontics
dc.subjectphysiology
dc.subjectrat
dc.subjecttibia
dc.subjectAnimals
dc.subjectBone Regeneration
dc.subjectBone Substitutes
dc.subjectCalcium Sulfate
dc.subjectCeramics
dc.subjectGuided Tissue Regeneration, Periodontal
dc.subjectImage Processing, Computer-Assisted
dc.subjectMale
dc.subjectMembranes, Artificial
dc.subjectRats
dc.subjectTibia
dc.titleBone healing in surgically created defects treated with either bioactive glass particles, a calcium sulfate barrier, or a combination of both materials: A histological and histometric study in rat tibiasen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes8399870097572073
unesp.author.lattes9831236034935598
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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