Effect of gender on training-induced vascular remodeling in SHR

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dc.contributor.authorAmaral, S. L. [UNESP]
dc.contributor.authorMichelini, L. C.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-29T01:01:42Z
dc.date.available2022-04-29T01:01:42Z
dc.date.issued2011-09-01
dc.description.abstractThere is accumulating evidence that physical inactivity, associated with the modern sedentary lifestyle, is a major determinant of hypertension. It represents the most important modifiable risk factor for cardiovascular diseases, which are the leading cause of morbidity and mortality for both men and women. In addition to involving sympathetic overactivity that alters hemodynamic parameters, hypertension is accompanied by several abnormalities in the skeletal muscle circulation including vessel rarefaction and increased arteriole wall-to-lumen ratio, which contribute to increased total peripheral resistance. Low-intensity aerobic training is a promising tool for the prevention, treatment and control of high blood pressure, but its efficacy may differ between men and women and between male and female animals. This review focuses on peripheral training-induced adaptations that contribute to a blood pressure-lowering effect, with special attention to differential responses in male and female spontaneously hypertensive rats (SHR). Heart, diaphragm and skeletal muscle arterioles (but not kidney arterioles) undergo eutrophic outward remodeling in trained male SHR, which contributed to a reduction of peripheral resistance and to a pressure fall. In contrast, trained female SHR showed no change in arteriole wall-to-lumen ratio and no pressure fall. On the other hand, training-induced adaptive changes in capillaries and venules (increased density) were similar in male and female SHR, supporting a similar hyperemic response to exercise.en
dc.description.affiliationDepartamento de Educação Física Faculdade de Ciências Universidade Estadual Paulista 'Júlio de Mesquita Filho', Bauru, SP
dc.description.affiliationDepartamento de Fisiologia e Biofísica Instituto de Ciências Biomédicas Universidade de São Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 São Paulo, SP
dc.description.affiliationDepartamento de Ciências Fisiológicas UNESP/UFSCAR Universidade Federal de São Carlos, São Carlos, SP
dc.description.affiliationUnespDepartamento de Educação Física Faculdade de Ciências Universidade Estadual Paulista 'Júlio de Mesquita Filho', Bauru, SP
dc.description.affiliationUnespDepartamento de Ciências Fisiológicas UNESP/UFSCAR Universidade Federal de São Carlos, São Carlos, SP
dc.format.extent814-826
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2011007500055
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 44, n. 9, p. 814-826, 2011.
dc.identifier.doi10.1590/S0100-879X2011007500055
dc.identifier.issn0100-879X
dc.identifier.issn1678-4510
dc.identifier.scopus2-s2.0-80053323714
dc.identifier.urihttp://hdl.handle.net/11449/226537
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.sourceScopus
dc.subjectArterioles
dc.subjectCapillaries
dc.subjectExercise training
dc.subjectHypertension
dc.subjectMicrocirculation
dc.subjectVenules
dc.titleEffect of gender on training-induced vascular remodeling in SHRen
dc.typeResenha
unesp.departmentEducação Física - FCpt

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Bauru - FC - Faculdade de Ciências