Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis

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Cacere, Camila R.
Mendes-Giannini, Maria José Soares [UNESP]
do Valle, Antonio Carlos F.
Duarte, Alberto J. S.
Benard, Gil

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Amer Soc Microbiology


To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.



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Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 16, n. 6, p. 953-955, 2009.