Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis
dc.contributor.author | Cacere, Camila R. | |
dc.contributor.author | Mendes-Giannini, Maria José Soares [UNESP] | |
dc.contributor.author | do Valle, Antonio Carlos F. | |
dc.contributor.author | Duarte, Alberto J. S. | |
dc.contributor.author | Benard, Gil | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Fiocruz MS | |
dc.date.accessioned | 2014-05-20T13:23:51Z | |
dc.date.available | 2014-05-20T13:23:51Z | |
dc.date.issued | 2009-06-01 | |
dc.description.abstract | To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis. | en |
dc.description.affiliation | Univ São Paulo, Sch Med, Lab Dermatol & Immunodeficiencies, BR-05403903 São Paulo, Brazil | |
dc.description.affiliation | São Paulo State Univ, Fac Pharmaceut Sci, Dept Clin Pathol, São Paulo, Brazil | |
dc.description.affiliation | Fiocruz MS, Inst Pesquisa Evandro Chagas, BR-21045900 Rio de Janeiro, Brazil | |
dc.description.affiliation | Univ São Paulo, Sch Med, Clin Hosp, Div Infect Dis,Syst Mycoses Outpatient Unit, BR-05403903 São Paulo, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ, Fac Pharmaceut Sci, Dept Clin Pathol, São Paulo, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | FAPESP: 02/10893-8 | |
dc.description.sponsorshipId | FAPESP: 02/07306-3 | |
dc.format.extent | 953-955 | |
dc.identifier | http://dx.doi.org/10.1128/CVI.00071-09 | |
dc.identifier.citation | Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 16, n. 6, p. 953-955, 2009. | |
dc.identifier.doi | 10.1128/CVI.00071-09 | |
dc.identifier.file | WOS000266638900025.pdf | |
dc.identifier.issn | 1556-6811 | |
dc.identifier.orcid | 0000-0002-8059-0826 | |
dc.identifier.uri | http://hdl.handle.net/11449/7262 | |
dc.identifier.wos | WOS:000266638900025 | |
dc.language.iso | eng | |
dc.publisher | Amer Soc Microbiology | |
dc.relation.ispartof | Clinical and Vaccine Immunology | |
dc.relation.ispartofjcr | 2.872 | |
dc.relation.ispartofsjr | 1,320 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis | en |
dc.type | Artigo | |
dcterms.license | http://journals.asm.org/site/misc/ASM_Author_Statement.xhtml | |
dcterms.rightsHolder | Amer Soc Microbiology | |
unesp.author.orcid | 0000-0002-8059-0826[2] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Análises Clínicas - FCF | pt |
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