Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis

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dc.contributor.authorCacere, Camila R.
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authordo Valle, Antonio Carlos F.
dc.contributor.authorDuarte, Alberto J. S.
dc.contributor.authorBenard, Gil
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFiocruz MS
dc.date.accessioned2014-05-20T13:23:51Z
dc.date.available2014-05-20T13:23:51Z
dc.date.issued2009-06-01
dc.description.abstractTo better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.en
dc.description.affiliationUniv São Paulo, Sch Med, Lab Dermatol & Immunodeficiencies, BR-05403903 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Fac Pharmaceut Sci, Dept Clin Pathol, São Paulo, Brazil
dc.description.affiliationFiocruz MS, Inst Pesquisa Evandro Chagas, BR-21045900 Rio de Janeiro, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Clin Hosp, Div Infect Dis,Syst Mycoses Outpatient Unit, BR-05403903 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Fac Pharmaceut Sci, Dept Clin Pathol, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 02/10893-8
dc.description.sponsorshipIdFAPESP: 02/07306-3
dc.format.extent953-955
dc.identifierhttp://dx.doi.org/10.1128/CVI.00071-09
dc.identifier.citationClinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 16, n. 6, p. 953-955, 2009.
dc.identifier.doi10.1128/CVI.00071-09
dc.identifier.fileWOS000266638900025.pdf
dc.identifier.issn1556-6811
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.urihttp://hdl.handle.net/11449/7262
dc.identifier.wosWOS:000266638900025
dc.language.isoeng
dc.publisherAmer Soc Microbiology
dc.relation.ispartofClinical and Vaccine Immunology
dc.relation.ispartofjcr2.872
dc.relation.ispartofsjr1,320
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleAltered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosisen
dc.typeArtigo
dcterms.licensehttp://journals.asm.org/site/misc/ASM_Author_Statement.xhtml
dcterms.rightsHolderAmer Soc Microbiology
unesp.author.orcid0000-0002-8059-0826[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas