Chemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta)

dc.contributor.authorRocha, Otavio P.
dc.contributor.authorDe Felicio, Rafael
dc.contributor.authorRodrigues, Ana Helena B.
dc.contributor.authorAmbrosio, Daniela L. [UNESP]
dc.contributor.authorCicarelli, Regina Maria Barretto [UNESP]
dc.contributor.authorDe Albuquerque, Sergio
dc.contributor.authorYoung, Maria Claudia M.
dc.contributor.authorYokoya, Nair S.
dc.contributor.authorDebonsi, Hosana M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Bot
dc.date.accessioned2014-05-20T13:24:19Z
dc.date.available2014-05-20T13:24:19Z
dc.date.issued2011-08-01
dc.description.abstractThe present study reports the Gas Chromatography-Mass Spectrometry (GC-MS) evaluation of the hexanes and dichloromethane fractions from extracts of the red alga Centroceras clavulatum (C. Agardh) Montagne. Twenty three compounds were identified, totaling ca. 42% of both fractions (0.18 g mass extract). The main constituents of the fractions were hexadecanoic acid (17.6%) and pentadecanoic acid (15.9%). Several secondary metabolites with interesting biological activity, such as (-)-loliolide, neophytadiene, phytol were identified. In addition, several classes of secondary metabolites, including phenolic compounds (e.g., phenylacetic acid), terpene derivatives, fatty acids, halogenated compound (e.g., 2-chlorocyclohexenol), lignoids, steroids, esters, amides (e.g., hexadecanamide), ketones, carboxylic acids, aldehydes and alcohols were observed. The occurrence of several of these structural classes is described for the first time in this species. The same fractions analyzed by GC-MS, and a separate set of polar fractions, were evaluated against two life cycle stages (epimastigote and trypomastigote forms) of the protozoan Trypanosoma cruzi and against phytopatogenic fungi Cladosporium cladosporiodes and C. sphaerospermum. The dichloromethane fraction was active against both T. cruzi forms (epimastigote IC(50) = 19.1 mu g.mL(-1) and trypomastigote IC(50) = 76.2 mu g.mL(-1)). The hexanes and ethyl acetate fractions also displayed activity against both fungi species (200 mu g) by TLC-bioautography.en
dc.description.affiliationFac Ciencias Farmaceut Ribeirao Preto USP, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationDept Ciencias Biol UNESP, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationFac Ciencias Farmaceut Ribeirao Preto USP, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationInst Bot, Nucleo Pesquisas Fisiol & Bioquim Vegetal, BR-04301012 São Paulo, Brazil
dc.description.affiliationInst Bot, Nucleo Pesquisas Ficol, BR-04301012 São Paulo, Brazil
dc.description.affiliationUnespDept Ciencias Biol UNESP, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent7105-7114
dc.identifierhttp://dx.doi.org/10.3390/molecules16087105
dc.identifier.citationMolecules. Basel: Mdpi Ag, v. 16, n. 8, p. 7105-7114, 2011.
dc.identifier.doi10.3390/molecules16087105
dc.identifier.fileWOS000294249100071.pdf
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/11449/7501
dc.identifier.wosWOS:000294249100071
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCentroceras clavulatumen
dc.subjectGC-MS analysisen
dc.subjectRhodophytaen
dc.subjecttrypanocidal activityen
dc.subjectantifungal activityen
dc.titleChemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta)en
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMdpi Ag
unesp.author.orcid0000-0002-2860-6659[7]
unesp.author.orcid0000-0003-2530-9226[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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