Mineral intake independent from gastric irritation or pica by cell-dehydrated rats

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dc.contributor.authorConstancio, Juliana [UNESP]
dc.contributor.authorPereira-Derderian, Daniela T. B. [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorDe Luca, Laurival A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:15Z
dc.date.available2014-05-20T13:46:15Z
dc.date.issued2011-10-24
dc.description.abstractGavage of 2 M NaCl (IG 2 M NaCl), a procedure to induce cell-dehydration-and water and 015 M NaCl intake in a two-bottle choice test-is also a potential gastric irritant. In this study, we assessed whether mineral intake induced by IG 2 M NaCl is associated with gastric irritation or production of pica in the rat. We first determined the amount of mineral solution (0.15 M NaCl, 0.15 M NaHCO3, 0.01 M KCl and 0.05 mM CaCl2) and water ingested in response to IG 2 M NaCl in a five-bottle test. Then, we used mineral solutions (0.01 M KCl and 0.15 M NaHCO3), whose intakes were significantly increased compared to controls, and water in three-bottle tests to test the gastric irritation hypothesis. The IG 2 M NaCl induced KCl and NaHCO3 intake that was not inhibited by gavage with gastric protectors Al(OH)(3) or NaHCO3. IG 2 M NaCl or gavage of 0.6 N acetic acid induced mild irritation, hyperemia, of the glandular part of the stomach. A gavage of 50% ethanol induced strong irritation seen as pinpoint ulcerations. Neither ethanol nor acetic acid induced any fluid intake. Neither IG 2 M NaCl nor acetic acid induced kaolin intake, a marker of pica in laboratory rats. Ethanol did induce kaolin intake. These results suggest that IG 2 M NaCl induced a mineral fluid intake not selective for sodium and independent from gastric irritation or pica. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 06/58829-7
dc.format.extent659-665
dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2011.07.010
dc.identifier.citationPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 104, n. 5, p. 659-665, 2011.
dc.identifier.doi10.1016/j.physbeh.2011.07.010
dc.identifier.fileWOS000296208200002.pdf
dc.identifier.issn0031-9384
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16344
dc.identifier.wosWOS:000296208200002
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofPhysiology & Behavior
dc.relation.ispartofjcr2.517
dc.relation.ispartofsjr1,088
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectDehydrationen
dc.subjectThirsten
dc.subjectSodium appetiteen
dc.subjectMineral licken
dc.subjectSelf-medicationen
dc.subjectGastric mucosaen
dc.titleMineral intake independent from gastric irritation or pica by cell-dehydrated ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-8270-2652[4]
unesp.author.orcid0000-0003-1167-4441[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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