Avalia��o da qualidade de c�psulas de fluconazol manipuladas comercializadas na regi�o de Araraquara (SP, Brasil)

dc.contributor.authorCorr�a, Josilene Chaves Ruela [UNESP]
dc.contributor.authorVanzela, Nath�lia Maia [UNESP]
dc.contributor.authorSilva, Ta�zia Dutra
dc.contributor.authorVianna-Soares, Cristina Duarte
dc.contributor.authorSalgado, H�rida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2018-12-11T16:56:54Z
dc.date.available2018-12-11T16:56:54Z
dc.date.issued2014-01-01
dc.description.abstractThe quality control of drugs has an important role in public health, in ensuring the efficacy and safety of medicines. In the public health system, compounding pharmacies play a vital part. They provide medicines tailored to the individual patient, for example dermatological products and specific doses for children. Unfortunately, many cases of compounded products falling below the minimum quality standard have been reported in Brazil. In this study, the quality of compounded 150 mg fluconazole capsules was assessed and the results were compared with values stipulated in the Brazilian pharmacopoeia. The results suggest that, while it is certainly possible to prepare products meeting pharmacopoeial specifications, there are pharmacies where the quality control is deficient or nonexistent. Fluconazole is an important drug in combatting fungal infections. The use of fluconazole in dosage forms manufactured without high standards of quality control is strongly linked to treatment failure and cases of intoxication, as well as the emergence of resistant microorganisms. This highlights the urgent need for process improvement in compounding pharmacies. There are validated methods that can be successfully employed for routine quality control analysis that can be implemented by any compounding pharmacy.en
dc.description.affiliationDepartamento de F�rmacos e Medicamentos Universidade Estadual Paulista UNESP, Rodovia Araraquara-Ja�, km 01
dc.description.affiliationDepartamento de Produtos Farmac�uticos Universidade Federal de Minas Gerais UFMG, Av. Pres. Ant�nio Carlos, 6627
dc.description.affiliationUnespDepartamento de F�rmacos e Medicamentos Universidade Estadual Paulista UNESP, Rodovia Araraquara-Ja�, km 01
dc.format.extent257-261
dc.identifier.citationRevista de Ciencias Farmaceuticas Basica e Aplicada, v. 35, n. 2, p. 257-261, 2014.
dc.identifier.issn2179-443X
dc.identifier.issn1808-4532
dc.identifier.scopus2-s2.0-84920870890
dc.identifier.urihttp://hdl.handle.net/11449/171755
dc.language.isoeng
dc.relation.ispartofRevista de Ciencias Farmaceuticas Basica e Aplicada
dc.relation.ispartofsjr0,131
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCompounded medicines
dc.subjectFluconazole
dc.subjectPublic health
dc.subjectQuality control
dc.titleAvalia��o da qualidade de c�psulas de fluconazol manipuladas comercializadas na regi�o de Araraquara (SP, Brasil)pt
dc.title.alternativeAssessment of the quality of compounded fluconazole capsules marketed in the region of Araraquara (SP, Brazil)en
dc.typeArtigo

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