Aryltetralols from Holostylis reniformis and syntheses of lignan analogous

Pereira, Marcos D.P. [UNESP]; Ferreira, Matheus R. [UNESP]; Messiano, Gisele B. [UNESP]; Cerávolo, Isabela Penna; Lopes, Lucia M.X. [UNESP]; Krettli, Antoniana U.

Aryltetralols from Holostylis reniformis and syntheses of lignan analogous

Arquivos

2-s2.0-84934941750.pdf (713.08 KB)

Data

2015-06-27

Autores

Pereira, Marcos D.P.

Ferreira, Matheus R.

Messiano, Gisele B.

Cerávolo, Isabela Penna

Lopes, Lucia M.X.

Krettli, Antoniana U.

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

Abstract Two new lignans, an aryltetralol and its methyl ether analogous, were isolated from Holostylis reniformis (Aristolochiaceae) together with futokadsurin C and (-)-8′-epi-aristoligone. The latter was also obtained as an enantiomeric mixture by synthesis and was transformed into aryltetralols and aryltetralenes that were subjected to chiral-HPLC separations. The compound structures were determined by spectroscopic methods. Several of these lignans had their antiplasmodial activity (against Plasmodium falciparum, W2 clone, anti-HRPII) and toxicity to mammalian kidney cells (MDL<inf>50</inf>) evaluated. (-)-Cyclogalgravin and (-)-aristoligol exhibited activity (IC<inf>50</inf> ∼ 10.8 and 8.4 μM, respectively), the latter exhibited lower toxicity.