Insights into HLA-G genetics provided by worldwide haplotype diversity

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dc.contributor.authorCastelli, Erick C. [UNESP]
dc.contributor.authorRamalho, Jaqueline [UNESP]
dc.contributor.authorPorto, Iane O. P. [UNESP]
dc.contributor.authorLima, Thalitta H. A. [UNESP]
dc.contributor.authorFelicio, Leandro P.
dc.contributor.authorSabbagh, Audrey
dc.contributor.authorDonadi, Eduardo A.
dc.contributor.authorMendes-Junior, CelsoT
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionMERIT
dc.contributor.institutionUniv Paris 05
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-11-03T15:27:43Z
dc.date.available2015-11-03T15:27:43Z
dc.date.issued2014-10-06
dc.description.abstractHuman leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function of class I non-classical genes. The main features that distinguish HLA-G from classical class I genes are (a) limited protein variability, (b) alternative splicing generating several membrane bound and soluble isoforms, (c) short cytoplasmic tail, (d) modulation of immune response (immune tolerance), and (e) restricted expression to certain tissues. In the present work, we describe the HLA-G gene structure and address the HLA-G variability and haplotype diversity among several populations around the world, considering each of its major segments [promoter, coding, and 3'untranslated region (UTR)] For this purpose, we developed a pipeline to reevaluate the 1000Genomes data and recover miscalled or missing genotypes and haplotypes. It became clear that the overall structure of the HLA-G molecule has been maintained during the evolutionary process and that most of the variation sites found in the HLA-G coding region are either coding synonymous or intronic mutations. In addition, only a few frequent and divergent extended haplotypes are found when the promoter, coding, and 3'UTRs are evaluated together. The divergence is particularly evident for the regulatory regions. The population comparisons confirmed that most of the HLA-G variability has originated before human dispersion from Africa and that the allele and haplotype frequencies have probably been shaped by strong selective pressures.en
dc.description.affiliationUniv Estadual Paulista, Sch Med Botucatu, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Goias, Inst Biol Sci, Goiania, Go, Brazil
dc.description.affiliationMERIT, Inst Rech Dev, UMR 216, Paris, France
dc.description.affiliationUniv Paris 05, Sorbonne Paris Cite, Fac Pharm, Paris, France
dc.description.affiliationUniv Sao Paulo, Sch Med Ribeirao Preto, Dept Med, Div Clin Immunol, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Filosofia Ciencias &Letras Ribeirao Preto, Dept Quim, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Med Botucatu, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPROPE/UNESP
dc.description.sponsorshipIdFAPESP: 2013/1708-42
dc.description.sponsorshipIdCNPq: 304471/2013-5
dc.description.sponsorshipIdCNPq: 304753/2009-2
dc.description.sponsorshipIdCNPq: 305493/2011-6
dc.format.extent27
dc.identifierhttp://journal.frontiersin.org/article/10.3389/fimmu.2014.00476/abstract
dc.identifier.citationFrontiers In Immunology. Lausanne: Frontiers Research Foundation, v. 5, 27 p., 2014.
dc.identifier.doi10.3389/fimmu.2014.00476
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/11449/129907
dc.identifier.wosWOS:000354476400001
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers In Immunology
dc.relation.ispartofjcr5.511
dc.relation.ispartofsjr2,803
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHLA-Gen
dc.subjectHaplotypesen
dc.subjectPolymorphismsen
dc.subjectVariabilityen
dc.subjectGene structure and diversityen
dc.subjectNon-classical HLAen
dc.subject1000Genomes Projecten
dc.subjectSelective pressureen
dc.titleInsights into HLA-G genetics provided by worldwide haplotype diversityen
dc.typeArtigo
dcterms.rightsHolderFrontiers Research Foundation
unesp.author.orcid0000-0003-0283-8803[6]
unesp.author.orcid0000-0002-7337-1203[8]
unesp.author.orcid0000-0003-2142-7196[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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