Polyphenol rich fruit attenuates genomic instability, modulates inflammation and cell cycle progression of offspring from fatty acid intake maternal

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dc.contributor.authorArgentato, Perla Pizzi
dc.contributor.authorPisani, Luciana Pellegrini
dc.contributor.authorDe Rosso, Veridiana Vera
dc.contributor.authorSoares, Glaucia Resende
dc.contributor.authorDias Silva, Marcelo Jose [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorRibeiro, Daniel Araki
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T01:48:05Z
dc.date.available2020-12-12T01:48:05Z
dc.date.issued2019-01-01
dc.description.abstractThe aim of this study was to investigate the effect of juçara (Euterpe edulis Mart.) supplementation on the maternal trans fatty acids intake in the livers of 21-day-old offspring. In order for this to happen, histopathological analysis, cytogenetic status, inflammation (COX-2 and TNF-alpha) and cell cycle progression were investigated in this setting. On the first day of pregnancy, female rats were distributed into four groups, as follows: control diet (C), control diet with 0.5 % juçara supplementation (CJ), diet enriched with hydrogenated vegetable fat, rich in TFAs (T), or T diet supplemented with 0.5 % juçara (TJ) during pregnancy and lactation. Juçara pulp induced liver regeneration in newborns exposed to maternal trans fatty acids. A significant decrease in the number of micronucleated hepatocytes was observed in animals exposed to trans fatty acids and treated with juçara. COX-2 and TNF immunoexpression was reduced in animals treated with juçara pulp. Furthermore, a decrease of Ki-67 immunoexpression was detected after treating trans fatty acids intake with juçara. Taken together, our results demonstrate that juçara pulp is able to prevent tissue degeneration and mutagenicity because it decreases inflammation and cell cycle control induced by maternal trans fatty acids in liver cells of rat offspring.en
dc.description.affiliationDepartment of Biosciences Federal University of Sao Paulo UNIFESP
dc.description.affiliationSao Paulo State University UNESP, Campus Litoral Paulista
dc.description.affiliationUnespSao Paulo State University UNESP, Campus Litoral Paulista
dc.identifierhttp://dx.doi.org/10.1016/j.pathophys.2019.11.002
dc.identifier.citationPathophysiology.
dc.identifier.doi10.1016/j.pathophys.2019.11.002
dc.identifier.issn1873-149X
dc.identifier.issn0928-4680
dc.identifier.scopus2-s2.0-85075857209
dc.identifier.urihttp://hdl.handle.net/11449/199743
dc.language.isoeng
dc.relation.ispartofPathophysiology
dc.sourceScopus
dc.subjectCell cycle progression
dc.subjectInflammation
dc.subjectMaternal fat diet
dc.subjectMicronucleus offspring
dc.subjectRat
dc.titlePolyphenol rich fruit attenuates genomic instability, modulates inflammation and cell cycle progression of offspring from fatty acid intake maternalen
dc.typeArtigo

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