Effect of different doses of 2,4-dichlorophenoxyacetic acid (2,4-d) on cardiac parameters in male Wistar rats

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dc.contributor.authorDe Oliveira Mantovani, Raíssa
dc.contributor.authorPinheiro, Dyovana Gomes
dc.contributor.authorDe Oliveira, Geovana Letícia Fernandes
dc.contributor.authorPerrud, Stéfani Nobrega
dc.contributor.authorTeixeira, Giovana Rampazzo [UNESP]
dc.contributor.authorNai, Gisele Alborghetti
dc.contributor.authorVeras, Allice Santos Cruz [UNESP]
dc.contributor.authorde Almeida Tavares, Maria Eduarda [UNESP]
dc.contributor.authorde Oliveira Mendes, Leonardo
dc.contributor.authorPacagnelli, Francis Lopes
dc.contributor.institutionUniversity of Western São Paulo (UNOESTE)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T01:37:34Z
dc.date.available2020-12-12T01:37:34Z
dc.date.issued2020-01-01
dc.description.abstractThe objective of this study was to evaluate the effects of different doses of 2,4-dichlorophenoxyacetic herbicide in rat hearts. Exposure was through rat food that was nebulized with the herbicide. Thirty adult male Wistar rats (200–300 g) were used. The diet was exposed to 2,4-D in two different doses (CG: control group 10 ml distilled water; LCG: low concentration group 3.71 × 10−3 g.ia/ha diluted in 10 ml saline at 0.9% and HCG: High concentration group 9.28 × 10−3 g.ia/ha diluted in 10 ml 0.9% saline). After 6 months of exposure, blood samples were collected for CKMB evaluation, and left ventricular fragments were analyzed by histological evaluation, fibrosis measurements, fractal dimension and immunohistochemistry (BAX, Bcl2, TNF-α and NF-kB). There were no significant changes in CK-MB concentration, histological parameters, fibrosis measurements and fractal dimension. Long-term oral consumption of food nebulized by the herbicide 2,4-D promoted an increase in BAX, Bcl-2/BAX, and cytoplasmic NF-kB in the nuclear area of the group that received the highest dose of the herbicide. This suggests that the herbicide induces cardiotoxicity.en
dc.description.affiliationPostgraduate Animal Science Program University of Western São Paulo (UNOESTE)
dc.description.affiliationFaculty of Health Sciences Physiotherapy University of Western São Paulo (UNOESTE)
dc.description.affiliationFaculty of Science and Technology São Paulo State University (UNESP)
dc.description.affiliationUnespFaculty of Science and Technology São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1007/s11356-020-10699-y
dc.identifier.citationEnvironmental Science and Pollution Research.
dc.identifier.doi10.1007/s11356-020-10699-y
dc.identifier.issn1614-7499
dc.identifier.issn0944-1344
dc.identifier.scopus2-s2.0-85090464167
dc.identifier.urihttp://hdl.handle.net/11449/199354
dc.language.isoeng
dc.relation.ispartofEnvironmental Science and Pollution Research
dc.sourceScopus
dc.subject2,4-Dichlorophenocycetic
dc.subjectApoptosis
dc.subjectCardiotoxicity
dc.subjectHerbicide
dc.titleEffect of different doses of 2,4-dichlorophenoxyacetic acid (2,4-d) on cardiac parameters in male Wistar ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-1962-2235[1]

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