Hyaluronic Acid Behavior in the Lamina Propria of the Larynx with Advancing Age

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dc.contributor.authorBranco, Anete [UNESP]
dc.contributor.authorRodrigues, Sergio Augusto
dc.contributor.authorFabro, Alexandre Todorovic [UNESP]
dc.contributor.authorFonseca-Alves, Carlos Eduardo [UNESP]
dc.contributor.authorGarcia Martins, Regina Helena [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSao Paulo State Technol Coll FATEC BT
dc.date.accessioned2015-03-18T15:55:46Z
dc.date.available2015-03-18T15:55:46Z
dc.date.issued2014-10-01
dc.description.abstractObjectives. To analyze the hyaluronic acid behavior in the lamina propria of the larynx with advancing age.Study Design. Prospective study.Setting. UNESP-Univ Estadual Paulista, Botucatu Medical School, Brazil.Subjects and Methods. Thirty vocal folds were obtained at necropsy from 10 adult males (30-50 years old) and 20 geriatric males (10: 60-75 years old; 10: over 76 years old). Midmembranous vocal fold sections were subjected to immunohistochemical reactions. Digital imaging software (ImageJ) was used to quantify the hyaluronic acid distribution over the lamina propria of vocal folds, from superficial to deep layers.Results. Hyaluronic acid distribution was homogeneous for the larynges, at both superficial and deep layers (41.6 and 38.5, respectively). For both 30- to 50-year-old men geriatric age groups, hyaluronic acid level was lower at both layers.Conclusion. Hyaluronic acid level in the lamina propria of the larynx of geriatric men decreases with advancing age at both layers of the lamina.en
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Head & Neck Surg, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Technol Coll FATEC BT, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Vet Med & Anim Sci, Vet Clin Dept, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Med Sch, Dept Head & Neck Surg, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Med Sch, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Sch Vet Med & Anim Sci, Vet Clin Dept, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent652-656
dc.identifierhttp://dx.doi.org/10.1177/0194599814544673
dc.identifier.citationOtolaryngology-head And Neck Surgery. London: Sage Publications Ltd, v. 151, n. 4, p. 652-656, 2014.
dc.identifier.doi10.1177/0194599814544673
dc.identifier.issn0194-5998
dc.identifier.lattes8683290712226765
dc.identifier.urihttp://hdl.handle.net/11449/117301
dc.identifier.wosWOS:000342982900020
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofOtolaryngology-head And Neck Surgery
dc.relation.ispartofjcr2.444
dc.relation.ispartofsjr1,374
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectlarynxen
dc.subjectlamina propriaen
dc.subjectvocal foldsen
dc.subjecthyaluronic aciden
dc.subjectpresbyphoniaen
dc.titleHyaluronic Acid Behavior in the Lamina Propria of the Larynx with Advancing Ageen
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Ltd
unesp.author.lattes8683290712226765
unesp.author.orcid0000-0002-7687-3161[3]
unesp.author.orcid0000-0002-2091-2141[2]
unesp.author.orcid0000-0002-6702-6139[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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