Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens

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dc.contributor.authorRodrigues, M. C. [UNESP]
dc.contributor.authorCooke, R. F.
dc.contributor.authorMarques, R. S.
dc.contributor.authorArispe, S. A.
dc.contributor.authorKeisler, D. H.
dc.contributor.authorBohnert, D. W.
dc.contributor.institutionOregon State Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Missouri
dc.date.accessioned2018-11-26T15:28:22Z
dc.date.available2018-11-26T15:28:22Z
dc.date.issued2015-10-01
dc.description.abstractThis study evaluated the effects of oral meloxicam administration on metabolic, inflammatory, and acute-phase responses of beef cattle receiving a lipopolysaccharide (LPS) challenge (Exp. 1; d - 1 to 6) or vaccinated against respiratory pathogens (Exp. 2; d 7 to 21). Twenty-one Angus steers (n = 11) and heifers (n = 10) were housed in individual pens on d - 15 and were offered free-choice water, mineral-vitamin mix, and hay until d 21. In Exp. 1, cattle were ranked on d - 1 by sex and BW and assigned to 1) oral meloxicam administration (1 mg/kg BW daily) from day - 1 to 6 (MEL8), 2) oral meloxicam administration (1 mg/kg BW) on d 0 and oral lactose monohydrate administration (1 mg/kg BW) on d - 1 and from d 1 to 6 (MEL1), or 3) oral lactose monohydrate administration (1 mg/kg BW daily) from d - 1 to 6 (CON). On d 0, cattle received an intravenous LPS bolus (0.5 mu g/kg BW) concurrently with treatment administration. Rectal temperature (RTEMP) was assessed, and blood samples were collected at -2, 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 60, 72, 96, 120, and 144 h relative to LPS administration. No treatment effects were detected (P >= 0.36) for RTEMP, concentrations of serum tumor necrosis factor a (TNF alpha), plasma haptoglobin, cortisol, insulin, and leptin, as well as blood mRNA expression of TNF alpha and cyclooxygenase-2, although all variables increased (P < 0.01) across treatments after LPS administration. In Exp. 2, cattle received the same treatments that they were assigned to in Exp. 1 from d 7 to d 13 and were vaccinated against respiratory pathogens concurrently with treatment administration on d 8. Blood samples were collected, and RTEMP was assessed as in Exp. 1 in addition to 168, 240, and 336 h relative to vaccination. No treatment effects were detected (P >= 0.26) for RTEMP, the same plasma and serum variables evaluated in Exp. 1, and serum concentrations of antibodies against Mannheimia haemolytica or serum titers against bovine respiratory syncytial virus, bovine herpesvirus-1, bovine viral diarrhea virus-1, and parainfluenza-3 virus. All variables increased (P < 0.01) across treatments after vaccination, except for serum TNF alpha and titers against bovine viral diarrhea virus-1 (P >= 0.40). Collectively, this study found no evidence that oral meloxicam administration, at the doses and intervals utilized herein, mitigated the metabolic, inflammatory, and acute-phase reactions elicited by LPS administration or vaccination against respiratory pathogens.en
dc.description.affiliationOregon State Univ, Eastern Oregon Agr Res Ctr, Burns, OR 97720 USA
dc.description.affiliationUniv Estadual Paulista, Programa Posgrad Zootecnia, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationOregon State Univ, Malheur Cty Extens Off, Toronto, ON 97914, Canada
dc.description.affiliationUniv Missouri, Dept Anim Sci, Columbia, MO 65211 USA
dc.description.affiliationUnespUniv Estadual Paulista, Programa Posgrad Zootecnia, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipUSDA-NIFA Oregon
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdUSDA-NIFA Oregon: ORE00121
dc.format.extent5018-5027
dc.identifierhttp://dx.doi.org/10.2527/jas.2015-9424
dc.identifier.citationJournal Of Animal Science. Champaign: Amer Soc Animal Science, v. 93, n. 10, p. 5018-5027, 2015.
dc.identifier.doi10.2527/jas.2015-9424
dc.identifier.fileWOS000366326100044.pdf
dc.identifier.issn0021-8812
dc.identifier.urihttp://hdl.handle.net/11449/158623
dc.identifier.wosWOS:000366326100044
dc.language.isoeng
dc.publisherAmer Soc Animal Science
dc.relation.ispartofJournal Of Animal Science
dc.relation.ispartofsjr0,848
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectbeef cattle
dc.subjectinflammation
dc.subjectlipopolysaccharide
dc.subjectmeloxicam
dc.subjectvaccination
dc.titleEffects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogensen
dc.typeArtigo
dcterms.rightsHolderAmer Soc Animal Science

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