Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens
dc.contributor.author | Rodrigues, M. C. [UNESP] | |
dc.contributor.author | Cooke, R. F. | |
dc.contributor.author | Marques, R. S. | |
dc.contributor.author | Arispe, S. A. | |
dc.contributor.author | Keisler, D. H. | |
dc.contributor.author | Bohnert, D. W. | |
dc.contributor.institution | Oregon State Univ | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Univ Missouri | |
dc.date.accessioned | 2018-11-26T15:28:22Z | |
dc.date.available | 2018-11-26T15:28:22Z | |
dc.date.issued | 2015-10-01 | |
dc.description.abstract | This study evaluated the effects of oral meloxicam administration on metabolic, inflammatory, and acute-phase responses of beef cattle receiving a lipopolysaccharide (LPS) challenge (Exp. 1; d - 1 to 6) or vaccinated against respiratory pathogens (Exp. 2; d 7 to 21). Twenty-one Angus steers (n = 11) and heifers (n = 10) were housed in individual pens on d - 15 and were offered free-choice water, mineral-vitamin mix, and hay until d 21. In Exp. 1, cattle were ranked on d - 1 by sex and BW and assigned to 1) oral meloxicam administration (1 mg/kg BW daily) from day - 1 to 6 (MEL8), 2) oral meloxicam administration (1 mg/kg BW) on d 0 and oral lactose monohydrate administration (1 mg/kg BW) on d - 1 and from d 1 to 6 (MEL1), or 3) oral lactose monohydrate administration (1 mg/kg BW daily) from d - 1 to 6 (CON). On d 0, cattle received an intravenous LPS bolus (0.5 mu g/kg BW) concurrently with treatment administration. Rectal temperature (RTEMP) was assessed, and blood samples were collected at -2, 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 60, 72, 96, 120, and 144 h relative to LPS administration. No treatment effects were detected (P >= 0.36) for RTEMP, concentrations of serum tumor necrosis factor a (TNF alpha), plasma haptoglobin, cortisol, insulin, and leptin, as well as blood mRNA expression of TNF alpha and cyclooxygenase-2, although all variables increased (P < 0.01) across treatments after LPS administration. In Exp. 2, cattle received the same treatments that they were assigned to in Exp. 1 from d 7 to d 13 and were vaccinated against respiratory pathogens concurrently with treatment administration on d 8. Blood samples were collected, and RTEMP was assessed as in Exp. 1 in addition to 168, 240, and 336 h relative to vaccination. No treatment effects were detected (P >= 0.26) for RTEMP, the same plasma and serum variables evaluated in Exp. 1, and serum concentrations of antibodies against Mannheimia haemolytica or serum titers against bovine respiratory syncytial virus, bovine herpesvirus-1, bovine viral diarrhea virus-1, and parainfluenza-3 virus. All variables increased (P < 0.01) across treatments after vaccination, except for serum TNF alpha and titers against bovine viral diarrhea virus-1 (P >= 0.40). Collectively, this study found no evidence that oral meloxicam administration, at the doses and intervals utilized herein, mitigated the metabolic, inflammatory, and acute-phase reactions elicited by LPS administration or vaccination against respiratory pathogens. | en |
dc.description.affiliation | Oregon State Univ, Eastern Oregon Agr Res Ctr, Burns, OR 97720 USA | |
dc.description.affiliation | Univ Estadual Paulista, Programa Posgrad Zootecnia, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, Brazil | |
dc.description.affiliation | Oregon State Univ, Malheur Cty Extens Off, Toronto, ON 97914, Canada | |
dc.description.affiliation | Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Programa Posgrad Zootecnia, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, Brazil | |
dc.description.sponsorship | USDA-NIFA Oregon | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | USDA-NIFA Oregon: ORE00121 | |
dc.format.extent | 5018-5027 | |
dc.identifier | http://dx.doi.org/10.2527/jas.2015-9424 | |
dc.identifier.citation | Journal Of Animal Science. Champaign: Amer Soc Animal Science, v. 93, n. 10, p. 5018-5027, 2015. | |
dc.identifier.doi | 10.2527/jas.2015-9424 | |
dc.identifier.file | WOS000366326100044.pdf | |
dc.identifier.issn | 0021-8812 | |
dc.identifier.uri | http://hdl.handle.net/11449/158623 | |
dc.identifier.wos | WOS:000366326100044 | |
dc.language.iso | eng | |
dc.publisher | Amer Soc Animal Science | |
dc.relation.ispartof | Journal Of Animal Science | |
dc.relation.ispartofsjr | 0,848 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | beef cattle | |
dc.subject | inflammation | |
dc.subject | lipopolysaccharide | |
dc.subject | meloxicam | |
dc.subject | vaccination | |
dc.title | Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens | en |
dc.type | Artigo | |
dcterms.rightsHolder | Amer Soc Animal Science |
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