Extracellular matrix in ocular homeostasis and diseases: The heroes, the villains, and the magic

Nenhuma Miniatura disponível

Data

2018-08-09

Orientador

Coorientador

Pós-graduação

Curso de graduação

Título da Revista

ISSN da Revista

Título de Volume

Editor

Tipo

Capítulo de livro

Direito de acesso

Resumo

The eyes are highly diversified photosensitive structures. In all vertebrates, eyes resemble in molecular composition and are predominantly composed of extracellular matrix (ECM). Compared with other structures, the eyes have ECM in unique arrangements. Because the ocular ECM is labile and dynamic, when remodeling, it may lead to a series of diseases or alterations that impair vision. Post-translational processing of ECM molecules of the eye can be impaired by multiple multifactorial conditions that trigger the onset of ocular diseases, including corneal dystrophies, glaucoma, macular degeneration, and tumors. Besides, the ECM is the link that connects the eyes to other structures of the body, so a variety of systemic hereditary or autoimmune connective tissue disorders can affect the ocular homeostasis. This work explores the dual role (from hero to a villain) of ECM in ocular homeostasis and diseases and discusses how this duality can be magically used to treat ocular diseases. The view on ECM biology offered by this work is translational and address concepts of basic science and clinicalsurgical issues.

Descrição

Idioma

Inglês

Como citar

Advances in Medicine and Biology, p. 1-104.

Itens relacionados

Financiadores