New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejuni

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dc.contributor.authorSilva, Raphael Tristão Cruvinel
dc.contributor.authorGuidotti-Takeuchi, Micaela
dc.contributor.authorPeixoto, Jéssica Laura Miranda
dc.contributor.authorDemarqui, Fernanda Manaia [UNESP]
dc.contributor.authorMori, Ananda Paula
dc.contributor.authorDumont, Carolyne Ferreira
dc.contributor.authorFerreira, Gabriella Rayane Aparecida
dc.contributor.authorPereira, Gabriele de Menezes
dc.contributor.authorRossi, Daise Aparecida
dc.contributor.authorCorbi, Pedro Paulo
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorRezende Júnior, Celso de Oliveira
dc.contributor.authorMelo, Roberta Torres de
dc.contributor.authorGuerra, Wendell
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2023-07-29T16:13:49Z
dc.date.available2023-07-29T16:13:49Z
dc.date.issued2023-05-01
dc.description.abstractThis work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1, [Pd(meg)(PPh3)2] 2, [Pd(og)(1,10-phen)] 3 and [Pd(og)(PPh3)2] 4, where meg = methyl gallate, og = octyl gallate, 1,10-phen = 1,10-phenanthroline and PPh3 = triphenylphosphine. As to the chemical structures, spectral and physicochemical studies of 1–4 indicated that methyl or octyl gallate coordinates a palladium(II) ion through two oxygen atoms upon deprotonation. A chelating bidentate phenanthroline or two triphenylphosphine molecules complete the coordination sphere of palladium(II) ion, depending on the complex. The metal complexes were tested against the Mycobacterium tuberculosis H37Rv strain and 2 exhibited high activity (MIC = 3.28 μg/mL). As to the tests with Campylobacter jejuni, complex 1 showed a significant effect in reducing bacterial population (greater than 7 log CFU) in planktonic forms, as well as in the biomass intensity (IBF: 0.87) when compared to peracetic acid (IBF: 1.11) at a concentration of 400 μg/mL. The effect provided by these complexes has specificity according to the target microorganism and represent a promising alternative for the control of microorganisms of public health importance.en
dc.description.affiliationInstitute of Chemistry Federal University of Uberlândia—UFU, Santa Mônica Campus, MG
dc.description.affiliationLaboratory of Experimental Molecular Epidemiology Federal University of Uberlândia—UFU, Umuarama Campus, MG
dc.description.affiliationFaculty of Pharmaceutical Sciences Paulista State University—UNESP, Araraquara Campus, SP
dc.description.affiliationInstitute of Chemistry State University of Campinas—UNICAMP, SP
dc.description.affiliationUnespFaculty of Pharmaceutical Sciences Paulista State University—UNESP, Araraquara Campus, SP
dc.identifierhttp://dx.doi.org/10.3390/molecules28093887
dc.identifier.citationMolecules, v. 28, n. 9, 2023.
dc.identifier.doi10.3390/molecules28093887
dc.identifier.issn1420-3049
dc.identifier.scopus2-s2.0-85159310229
dc.identifier.urihttp://hdl.handle.net/11449/249955
dc.language.isoeng
dc.relation.ispartofMolecules
dc.sourceScopus
dc.subjectanti-infective drugs
dc.subjectantibacterial activity
dc.subjectCampylobacter jejuni
dc.subjectMycobacterium tuberculosis
dc.subjectpalladium(II) complexes
dc.titleNew Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejunien
dc.typeArtigo
unesp.author.orcid0000-0003-2003-696X[9]
unesp.author.orcid0000-0002-6969-3963[11]
unesp.author.orcid0000-0003-1402-2035[12]
unesp.author.orcid0000-0001-8265-5163[13]
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas