Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite

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dc.contributor.authorKollath, V. Ozhukil [UNESP]
dc.contributor.authorMullens, S.
dc.contributor.authorLuyten, J.
dc.contributor.authorTraina, K.
dc.contributor.authorCloots, R.
dc.contributor.institutionUniv Liege
dc.contributor.institutionFlemish Inst Technol Res VITO
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionKatholieke Univ Leuven
dc.contributor.institutionGalephar SA
dc.date.accessioned2018-11-26T15:29:22Z
dc.date.available2018-11-26T15:29:22Z
dc.date.issued2016-01-01
dc.description.abstractHydroxyapatite (HA) is a promising carrier material for oral delivery of biomolecules such as proteins and drugs. Ways to increase the loading of such molecules on HA will lead to better nanomedicine. This study reports the surface functionalisation of HA particles using the mussel inspired molecules dopamine (DA) and 3,4-dihydroxy-L-phenylalanine (DOPA), in order to increase protein loading. The adsorption mechanisms are discussed based on the adsorption isotherms, zeta potential, thermal analysis and theoretical models. Results show that DA functionalisation enhanced the loading, while DOPA functionalisation was ineffective.en
dc.description.affiliationUniv Liege, Dept Chem, GREEnMat, B6a SartTilman, B-4000 Liege, Belgium
dc.description.affiliationFlemish Inst Technol Res VITO, Sustainable Mat Management, Boeretang 200, B-2400 Mol, Belgium
dc.description.affiliationUniv Estadual Paulista, Lab Anelast & Biomat, Fac Sci, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationKatholieke Univ Leuven, Dept Met & Mat Engn, B-3001 Heverlee, Belgium
dc.description.affiliationGalephar SA, B-6900 Marche Enfamenne, Belgium
dc.description.affiliationUnespUniv Estadual Paulista, Lab Anelast & Biomat, Fac Sci, BR-17033360 Bauru, SP, Brazil
dc.description.sponsorshipVITO
dc.description.sponsorshipUniversity of Liege
dc.format.extent241-245
dc.identifierhttp://dx.doi.org/10.1179/1753555715Y.0000000048
dc.identifier.citationMaterials Technology. Abingdon: Taylor & Francis Ltd, v. 31, n. 4, p. 241-245, 2016.
dc.identifier.doi10.1179/1753555715Y.0000000048
dc.identifier.fileWOS000374885600011.pdf
dc.identifier.issn1066-7857
dc.identifier.urihttp://hdl.handle.net/11449/158831
dc.identifier.wosWOS:000374885600011
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofMaterials Technology
dc.relation.ispartofsjr0,352
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHydroxyapatite
dc.subjectProtein
dc.subjectDopamine
dc.subjectAdsorption isotherm
dc.subjectOral delivery
dc.titleEffect of DOPA and dopamine coupling on protein loading of hydroxyapatiteen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd

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