Evidence that fibroblast growth factor 10 plays a role in follicle selection in cattle

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dc.contributor.authorCastilho, A. C. S. [UNESP]
dc.contributor.authorPrice, C. A.
dc.contributor.authorDalanezi, F. [UNESP]
dc.contributor.authorEreno, R. L. [UNESP]
dc.contributor.authorMachado, M. F. [UNESP]
dc.contributor.authorBarros, C. M. [UNESP]
dc.contributor.authorGasperin, B. G.
dc.contributor.authorGoncalves, P. B. D.
dc.contributor.authorBuratini, J. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Montreal
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.date.accessioned2018-11-28T03:24:29Z
dc.date.available2018-11-28T03:24:29Z
dc.date.issued2017-01-01
dc.description.abstractThere is evidence that regulation of follicle selection in cattle involves locally produced growth factors. In the present study, we investigated the expression of members of the fibroblast growth factor (FGF) 7 family during follicle deviation. The largest and second largest follicles were recovered during the second day of a synchronised follicle wave and the future dominant and future subordinate follicles were identified based on diameter and cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1) mRNA levels in granulosa cells. Theca cells of the future dominant follicle contained less mRNA encoding FGF7 and FGF10 compared with those from the future subordinate follicle 2.5 days after ovulation, before a significant difference between the diameters of the future dominant and future subordinate follicles could be observed, but FGF22 mRNA levels did not change. Levels of mRNA encoding FGF receptors FGFR1B and FGFR2B in theca and granulosa cells, respectively, were lower in the future dominant follicle compared with the future subordinate follicle. Addition of FGF10 to granulosa cells in vitro significantly decreased oestradiol secretion, as well as CYP19A1, FSH receptor (FSHR) and insulin-like growth factor 1 receptor (IGF1R) mRNA abundance, whereas FGF22 had no effect. We conclude that FGF10 and FGFR2B expression is increased in the future subordinate follicle before morphological deviation, which may contribute to follicle selection.en
dc.description.affiliationUniv Estadual Paulista, Dept Farmacol, Inst Biociencias, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUniv Montreal, Fac Med Vet, Ctr Rech Reprod Anim, 3200 Sicotte, St Hyacinthe, PQ J2S 7C6, Canada
dc.description.affiliationUniv Fed Santa Maria, Lab Biotecnol & Reprod Anim, Ave Roraima 1000, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Fisiol, Inst Biociencias, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Farmacol, Inst Biociencias, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fisiol, Inst Biociencias, BR-18618970 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipACSC
dc.description.sponsorshipIdFAPESP: 2008/57365-2
dc.format.extent234-243
dc.identifierhttp://dx.doi.org/10.1071/RD15017
dc.identifier.citationReproduction Fertility And Development. Clayton: Csiro Publishing, v. 29, n. 2, p. 234-243, 2017.
dc.identifier.doi10.1071/RD15017
dc.identifier.fileWOS000392134500002.pdf
dc.identifier.issn1031-3613
dc.identifier.urihttp://hdl.handle.net/11449/165439
dc.identifier.wosWOS:000392134500002
dc.language.isoeng
dc.publisherCsiro Publishing
dc.relation.ispartofReproduction Fertility And Development
dc.relation.ispartofsjr0,681
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectantral follicles
dc.subjectbovine
dc.subjectdeviation
dc.subjectovary
dc.titleEvidence that fibroblast growth factor 10 plays a role in follicle selection in cattleen
dc.typeArtigo
dcterms.rightsHolderCsiro Publishing

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