Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy

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dc.contributor.authorGuerra, Renan B. [UNESP]
dc.contributor.authorGálico, Diogo A. [UNESP]
dc.contributor.authorHolanda, Bruno B. C. [UNESP]
dc.contributor.authorBannach, Gilbert [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:01:29Z
dc.date.available2018-12-11T17:01:29Z
dc.date.issued2016-03-01
dc.description.abstractSimultaneous thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry-optical microscopy (DSC-optical microscopy), online coupled thermogravimetry-infrared spectroscopy evolved gas analyses (TG-EGA-MIR), and spectroscopic techniques were used to study the non-steroidal anti-inflammatory drug sulindac in polymorphic form II. The TG-DSC curves, which were performed with the aid of DSC-optical microscopy, provided information concerning the thermal stability and decomposition profiles of the compound. From the TG-EGA-MIR coupled technique, it was possible to identify formaldehyde as a volatile compound that was released during thermal decomposition. A complete spectroscopic characterization in the ultraviolet, visible, near- and middle-infrared regions was performed in order to understand the spectroscopic properties of sulindac form II.en
dc.description.affiliationFaculdade de Ciências Departamento de Química UNESP - Univ. Estadual Paulista
dc.description.affiliationUnespFaculdade de Ciências Departamento de Química UNESP - Univ. Estadual Paulista
dc.format.extent2523-2530
dc.identifierhttp://dx.doi.org/10.1007/s10973-015-5228-2
dc.identifier.citationJournal of Thermal Analysis and Calorimetry, v. 123, n. 3, p. 2523-2530, 2016.
dc.identifier.doi10.1007/s10973-015-5228-2
dc.identifier.file2-s2.0-84959488201.pdf
dc.identifier.issn1588-2926
dc.identifier.issn1388-6150
dc.identifier.scopus2-s2.0-84959488201
dc.identifier.urihttp://hdl.handle.net/11449/172622
dc.language.isoeng
dc.relation.ispartofJournal of Thermal Analysis and Calorimetry
dc.relation.ispartofsjr0,587
dc.relation.ispartofsjr0,587
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCoupled TG-EGA-MIR
dc.subjectDSC-optical microscopy
dc.subjectSpectroscopic studies
dc.subjectSulindac
dc.subjectThermal behavior
dc.titleSolid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopyen
dc.typeArtigo
unesp.departmentQuímica - FCpt

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