Índice preditor de reserva ovariana (ORPI) para controle de estimulação ovariana individualizado

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dc.contributor.authorOliveira, Joao Batista A. [UNESP]
dc.contributor.authorPetersen, Claudia G. [UNESP]
dc.contributor.authorMauri, Ana L.
dc.contributor.authorCavagna, Mario
dc.contributor.authorBaruffi, Ricardo L R.
dc.contributor.authorFranco Junior, Jose Gonçalves [UNESP]
dc.contributor.institutionCentre for Human Reproduction Prof. Franco Junior
dc.contributor.institutionPaulista Centre for Diagnosis, Research and Training
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPerola Byington Hospital
dc.date.accessioned2014-05-27T11:29:06Z
dc.date.available2014-05-27T11:29:06Z
dc.date.issued2013-05-03
dc.description.abstractObjective: to expand the evaluation of a new ovarian response prediction index (ORPI), which was based on the AMH, AFC and age, and to verify its reability as a predictor of ovarian response to stimulation in assisted reproductive technology (ART) cycles. Methods: A total of 129 patients enrolled in the ICSI programme were included. The ORPI values were calculated by multiplying the AMH level (ng/ml) by the number of antral follicles (2-9 mm), and the result was divided by the age (years) of the patient (ORPI=(AMH × AFC)/Patient age). Results: Spearman's test revealed significant correlations (P<0.0001) between the ORPI and the number of oocytes collected and the number of follicles. Logistic regression revealed that ORPI values were significantly associated with the likelihood of collecting ≥4 oocytes (OR=45.56), ≥4 MII oocytes (OR=6.01) and ≥15 oocytes (OR=6.15; P<0.0001). Based on the ROC curves, the ORPI accurately predicted a low ovarian response (<4 oocytes retrieved; area under the curve (AUC):0.91), collection of ≥4 MII oocytes (AUC:0.85) and an excessive ovarian response (≥15 oocytes retrieved; AUC:0.89). Conclusions: The ORPI exhibited an excellent ability to predict a low ovarian response and a good ability to predict a collection of ≥ 4 MII oocytes, an excessive ovarian response. The ORPI might be used to improve the cost-benefit ratio of ovarian stimulation regimens by guiding the selection of medications and by modulating the doses and regimens according to the actual needs of the patients. © Todos os direitos reservados a SBRA - Sociedade Brasileira de Reprodução Assistida.en
dc.description.affiliationCentre for Human Reproduction Prof. Franco Junior, Preto, Ribeirao
dc.description.affiliationPaulista Centre for Diagnosis, Research and Training, Preto, Ribeirao
dc.description.affiliationDepartment of Gynaecology and Obstetrics Botucatu Medical School São Paulo State University, UNESP, Botucatu
dc.description.affiliationWomen's Health Reference Centre Perola Byington Hospital, Paulo, Sao
dc.description.affiliationUnespDepartment of Gynaecology and Obstetrics Botucatu Medical School São Paulo State University, UNESP, Botucatu
dc.format.extent77-83
dc.identifier.citationJornal Brasileiro de Reproducao Assistida, v. 17, n. 2, p. 77-83, 2013.
dc.identifier.issn1517-5693
dc.identifier.issn1518-0557
dc.identifier.scopus2-s2.0-84876865438
dc.identifier.urihttp://hdl.handle.net/11449/75350
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofJornal Brasileiro de Reproducao Assistida
dc.relation.ispartofsjr0,282
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAge
dc.subjectAnti-Mullerian hormone
dc.subjectAntral follicles
dc.subjectIndividualized controlled ovarian stimulation
dc.subjectOvarian response prediction index
dc.subjectcetrorelix
dc.subjectchorionic gonadotropin
dc.subjectleuprorelin
dc.subjectluteinizing hormone
dc.subjectMuellerian inhibiting factor
dc.subjectrecombinant follitropin
dc.subjectadult
dc.subjectage
dc.subjectcost benefit analysis
dc.subjectdrug dose increase
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectnamed inventories, questionnaires and rating scales
dc.subjectoocyte
dc.subjectovarian response prediction index
dc.subjectovary follicle
dc.subjectovary function
dc.subjecttransvaginal echography
dc.titleÍndice preditor de reserva ovariana (ORPI) para controle de estimulação ovariana individualizadopt
dc.title.alternativeExpand evaluation of the ovarian response prediction index (ORPI) for individualised controlled ovarian stimulationen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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