Hereditary microphthalmia in Texel lambs in Brazil

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Gonçalves, Maiara Aline
Pereira, Paula Reis
da Cruz, Raquel Aparecida Sales
Panziera, Welden
de Andrade, Danilo Giorgi Abranches [UNESP]
de Oliveira-Filho, José Paes [UNESP]
Borges, Alexandre Secorun [UNESP]
Sonne, Luciana
Driemeier, David

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On a farm in southern Brazil, four lambs in a flock of 300 Texel sheep were born with bilateral blindness. They revealed bilateral occlusion of the eyelids and were unresponsive to external visual stimuli and were disoriented when walking. A post-mortem examination revealed bilateral occlusion of the eyelids and, microscopically, total or partial absence of the lens was observed. Blood samples from 20% of the herd (61/300) were sent for molecular analysis. The four affected lambs were homozygous (C/C) for a mutation (single-nucleotide polymorphism c.338G > C) in the PITX3 gene, and 26.2% (16/61) of the herd, including the two ewe and two ram parents, were heterozygous (G/C). Based on clinical, pathological and molecular analysis, it was possible to determine the existence of hereditary microphthalmia in Texel lambs associated with the c.338G > C SNP in the PITX3 gene for the first time in Brazil. The result of this study provides a warning to veterinarians and breeders, emphasizing the importance of considering this disease in the differential diagnosis of congenital diseases in the Brazilian Texel flock.



Blindness, Congenital abnormalities, Eye diseases, Sheep, Texel

Como citar

Small Ruminant Research, v. 160, p. 1-4.