Hereditary microphthalmia in Texel lambs in Brazil
dc.contributor.author | Gonçalves, Maiara Aline | |
dc.contributor.author | Pereira, Paula Reis | |
dc.contributor.author | da Cruz, Raquel Aparecida Sales | |
dc.contributor.author | Panziera, Welden | |
dc.contributor.author | de Andrade, Danilo Giorgi Abranches [UNESP] | |
dc.contributor.author | de Oliveira-Filho, José Paes [UNESP] | |
dc.contributor.author | Borges, Alexandre Secorun [UNESP] | |
dc.contributor.author | Sonne, Luciana | |
dc.contributor.author | Driemeier, David | |
dc.contributor.institution | Universidade Federal do Rio Grande do Sul (UFRGS) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2018-12-11T17:17:18Z | |
dc.date.available | 2018-12-11T17:17:18Z | |
dc.date.issued | 2018-03-01 | |
dc.description.abstract | On a farm in southern Brazil, four lambs in a flock of 300 Texel sheep were born with bilateral blindness. They revealed bilateral occlusion of the eyelids and were unresponsive to external visual stimuli and were disoriented when walking. A post-mortem examination revealed bilateral occlusion of the eyelids and, microscopically, total or partial absence of the lens was observed. Blood samples from 20% of the herd (61/300) were sent for molecular analysis. The four affected lambs were homozygous (C/C) for a mutation (single-nucleotide polymorphism c.338G > C) in the PITX3 gene, and 26.2% (16/61) of the herd, including the two ewe and two ram parents, were heterozygous (G/C). Based on clinical, pathological and molecular analysis, it was possible to determine the existence of hereditary microphthalmia in Texel lambs associated with the c.338G > C SNP in the PITX3 gene for the first time in Brazil. The result of this study provides a warning to veterinarians and breeders, emphasizing the importance of considering this disease in the differential diagnosis of congenital diseases in the Brazilian Texel flock. | en |
dc.description.affiliation | Faculdade de Medicina Veterinária Universidade Federal do Rio Grande do Sul (UFRGS) Departamento de Patologia Veterinária, Av. Bento Gonçalves 9090 | |
dc.description.affiliation | Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) Campus Botucatu Departamento de Clínica Veterinária, Rua Prof. Doutor Walter Mauricio Correa s/n | |
dc.description.affiliationUnesp | Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) Campus Botucatu Departamento de Clínica Veterinária, Rua Prof. Doutor Walter Mauricio Correa s/n | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | CAPES: 1328442 | |
dc.format.extent | 1-4 | |
dc.identifier | http://dx.doi.org/10.1016/j.smallrumres.2017.12.012 | |
dc.identifier.citation | Small Ruminant Research, v. 160, p. 1-4. | |
dc.identifier.doi | 10.1016/j.smallrumres.2017.12.012 | |
dc.identifier.file | 2-s2.0-85040349294.pdf | |
dc.identifier.issn | 0921-4488 | |
dc.identifier.scopus | 2-s2.0-85040349294 | |
dc.identifier.uri | http://hdl.handle.net/11449/175737 | |
dc.language.iso | eng | |
dc.relation.ispartof | Small Ruminant Research | |
dc.relation.ispartofsjr | 0,485 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Blindness | |
dc.subject | Congenital abnormalities | |
dc.subject | Eye diseases | |
dc.subject | Sheep | |
dc.subject | Texel | |
dc.title | Hereditary microphthalmia in Texel lambs in Brazil | en |
dc.type | Artigo | |
unesp.author.lattes | 9643433706163946[7] | |
unesp.author.orcid | 0000-0001-6256-8089[7] |
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