Hereditary microphthalmia in Texel lambs in Brazil

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dc.contributor.authorGonçalves, Maiara Aline
dc.contributor.authorPereira, Paula Reis
dc.contributor.authorda Cruz, Raquel Aparecida Sales
dc.contributor.authorPanziera, Welden
dc.contributor.authorde Andrade, Danilo Giorgi Abranches [UNESP]
dc.contributor.authorde Oliveira-Filho, José Paes [UNESP]
dc.contributor.authorBorges, Alexandre Secorun [UNESP]
dc.contributor.authorSonne, Luciana
dc.contributor.authorDriemeier, David
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:17:18Z
dc.date.available2018-12-11T17:17:18Z
dc.date.issued2018-03-01
dc.description.abstractOn a farm in southern Brazil, four lambs in a flock of 300 Texel sheep were born with bilateral blindness. They revealed bilateral occlusion of the eyelids and were unresponsive to external visual stimuli and were disoriented when walking. A post-mortem examination revealed bilateral occlusion of the eyelids and, microscopically, total or partial absence of the lens was observed. Blood samples from 20% of the herd (61/300) were sent for molecular analysis. The four affected lambs were homozygous (C/C) for a mutation (single-nucleotide polymorphism c.338G > C) in the PITX3 gene, and 26.2% (16/61) of the herd, including the two ewe and two ram parents, were heterozygous (G/C). Based on clinical, pathological and molecular analysis, it was possible to determine the existence of hereditary microphthalmia in Texel lambs associated with the c.338G > C SNP in the PITX3 gene for the first time in Brazil. The result of this study provides a warning to veterinarians and breeders, emphasizing the importance of considering this disease in the differential diagnosis of congenital diseases in the Brazilian Texel flock.en
dc.description.affiliationFaculdade de Medicina Veterinária Universidade Federal do Rio Grande do Sul (UFRGS) Departamento de Patologia Veterinária, Av. Bento Gonçalves 9090
dc.description.affiliationFaculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) Campus Botucatu Departamento de Clínica Veterinária, Rua Prof. Doutor Walter Mauricio Correa s/n
dc.description.affiliationUnespFaculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) Campus Botucatu Departamento de Clínica Veterinária, Rua Prof. Doutor Walter Mauricio Correa s/n
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCAPES: 1328442
dc.format.extent1-4
dc.identifierhttp://dx.doi.org/10.1016/j.smallrumres.2017.12.012
dc.identifier.citationSmall Ruminant Research, v. 160, p. 1-4.
dc.identifier.doi10.1016/j.smallrumres.2017.12.012
dc.identifier.file2-s2.0-85040349294.pdf
dc.identifier.issn0921-4488
dc.identifier.scopus2-s2.0-85040349294
dc.identifier.urihttp://hdl.handle.net/11449/175737
dc.language.isoeng
dc.relation.ispartofSmall Ruminant Research
dc.relation.ispartofsjr0,485
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBlindness
dc.subjectCongenital abnormalities
dc.subjectEye diseases
dc.subjectSheep
dc.subjectTexel
dc.titleHereditary microphthalmia in Texel lambs in Brazilen
dc.typeArtigo
unesp.author.lattes9643433706163946[7]
unesp.author.orcid0000-0001-6256-8089[7]

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Artigos - Clínica Veterinária - FMVZ