Publicação:
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium

dc.contributor.authorBeline, Thamara
dc.contributor.authorde Almeida, Amanda B.
dc.contributor.authorAzevedo Neto, Nilton F. [UNESP]
dc.contributor.authorMatos, Adaias O.
dc.contributor.authorRicomini-Filho, Antônio P.
dc.contributor.authorSukotjo, Cortino
dc.contributor.authorSmeets, Paul J.M.
dc.contributor.authorda Silva, José H.D. [UNESP]
dc.contributor.authorNociti, Francisco H.
dc.contributor.authorBarão, Valentim A.R.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionTribocorrosion and Nanomedicine (IBTN)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCollege of Dentistry
dc.contributor.institutionNorthwestern University
dc.date.accessioned2020-12-12T01:20:36Z
dc.date.available2020-12-12T01:20:36Z
dc.date.issued2020-08-01
dc.description.abstractIn this study, β-tantalum oxide (β-Ta2O5) thin film was synthesized via magnetron sputtering to improve the surface properties, cytocompatibility and electrochemical stability of titanium. X-ray diffraction analysis confirmed a crystalline orthorhombic phase of Ta2O5 film on the β-Ta2O5 experimental surface. A granular structure with a complex and hierarchical nature was demonstrated by atomic force microscopy. Ta2O5-treated surfaces exhibited greater roughness and hydrophilicity compared with untreated titanium discs (control). Enhanced electrochemical stability in simulated body fluid (pH 7.4) was noted for Ta2O5-treated surfaces wherein higher values of charge transfer resistance, nobler corrosion potential, and lower capacitance, corrosion current density, and corrosion rate values were observed vs untreated control. Real-time monitoring of albumin and fibrinogen proteins adsorption by an electrochemical quartz crystal microbalance disclosed similar protein interactions for control and Ta2O5-treated discs, with higher fibrinogen adsorption rates for Ta2O5-treated surfaces. Cell culture assays (MC3T3-E1 cells) demonstrated that Ta2O5-treated discs featured greater in vitro mineral nodule formation, normal cell morphology and spreading, and increased mRNA levels of runt-related transcription factor 2 (Runx-2), osteocalcin (Ocn), and collagen-1 (Col-1). Therefore, it can be concluded that β-Ta2O5 thin films may be considered a promising strategy to trigger superior long-term stability and biological properties of titanium implants.en
dc.description.affiliationUniversity of Campinas (UNICAMP) Piracicaba Dental School Department of Prosthodontics and Periodontics, Av. Limeira, 901
dc.description.affiliationInstitute of Biomaterials Tribocorrosion and Nanomedicine (IBTN)
dc.description.affiliationSão Paulo State University (UNESP) School of Sciences Department of Physics, Av. Eng. Luís Edmundo C. Coube, 14-01
dc.description.affiliationUniversity of Campinas (UNICAMP) Piracicaba Dental School Department of Physiological Science, Av. Limeira, 901
dc.description.affiliationUniversity of Illinois at Chicago College of Dentistry Department of Restorative Dentistry, 801 S. Paulina
dc.description.affiliationDepartment of Materials Science and Engineering Northwestern University
dc.description.affiliationNUANCE Center Northwestern University
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Sciences Department of Physics, Av. Eng. Luís Edmundo C. Coube, 14-01
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipW. M. Keck Foundation
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipMaterials Research Science and Engineering Center, Harvard University
dc.description.sponsorshipIdFAPESP: 2016/07269-3
dc.description.sponsorshipIdFAPESP: 2016/11470-6
dc.description.sponsorshipIdFAPESP: 2017/18916-2
dc.description.sponsorshipIdMaterials Research Science and Engineering Center, Harvard University: NSF DMR-1720139
dc.identifierhttp://dx.doi.org/10.1016/j.apsusc.2020.146326
dc.identifier.citationApplied Surface Science, v. 520.
dc.identifier.doi10.1016/j.apsusc.2020.146326
dc.identifier.issn0169-4332
dc.identifier.scopus2-s2.0-85083268587
dc.identifier.urihttp://hdl.handle.net/11449/198732
dc.language.isoeng
dc.relation.ispartofApplied Surface Science
dc.sourceScopus
dc.subjectBiomaterials
dc.subjectCorrosion
dc.subjectDental implants
dc.subjectMagnetron sputtering
dc.subjectProtein adsorption
dc.subjectTantalum oxide
dc.titleβ-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titaniumen
dc.typeArtigo
dspace.entity.typePublication

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