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PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution

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dc.contributor.authorMainardes, R. M.
dc.contributor.authorEvangelista, R. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:27Z
dc.date.available2014-05-20T13:24:27Z
dc.date.issued2005-02-16
dc.description.abstractPraziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical nanoparticulate drug carriers made of poly(D,L-lactide-co-glycolide) acid with controlled size were designed. Praziquantel, a hydrophobic molecule, was entrapped into the nanoparticles with theoretical loading varying from 10 to 30% (w/w). This investigates the effects of some process variables on the size distribution of nanoparticles prepared by emulsion-solvent evaporation method. The results show that sonication time, PLGA and drug amounts, PVA concentration, ratio between aqueous and organic phases, and the method of solvent evaporation have a significant influence on size distribution of the nanoparticles. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Programa Posgrad Ciências Farmaceut, BR-14802902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Programa Posgrad Ciências Farmaceut, BR-14802902 Araraquara, SP, Brazil
dc.format.extent137-144
dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2004.11.027
dc.identifier.citationInternational Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 290, n. 1-2, p. 137-144, 2005.
dc.identifier.doi10.1016/j.ijpharm.2004.11.027
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/11449/7591
dc.identifier.wosWOS:000226985500015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.ispartofjcr3.862
dc.relation.ispartofsjr1,172
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectnanoparticlespt
dc.subjectcontrolled releasept
dc.subjectPLGApt
dc.subjectpraziquantelpt
dc.subjectemulsification evaporation methodpt
dc.titlePLGA nanoparticles containing praziquantel: effect of formulation variables on size distributionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0002-4442-2075[1]

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