Lack of genotoxicity of formocresol, paramonochlorophenol, and calcium hydroxide on mammalian cells by comet assay

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dc.contributor.authorRibeiro, Daniel Araki [UNESP]
dc.contributor.authorMarques, Mariângela Esther Alencar [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:07Z
dc.date.available2014-05-27T11:21:07Z
dc.date.issued2004-08-01
dc.description.abstractFormocresol, paramonochlorophenol, and calcium hydroxide are widely used in dentistry because of their antibacterial activities in root canal disinfection. However, the results of genotoxicity studies using these materials are inconsistent in literature. The goal of this study was to examine the genotoxic potential of formocresol, paramonochlorophenol, and calcium hydroxide using mouse lymphoma cells and human fibroblasts cells in vitro by the comet assay. Data were assessed by Kruskal-Wallis nonparametric test. The results showed that all compounds tested did not cause DNA damage for the tail moment or tail intensity parameters. These findings suggest that formocresol, paramonochlorophenol, and calcium hydroxide do not promote DNA damage in mammalian cells and that the comet assay is a suitable tool to investigate genotoxicity.en
dc.description.affiliationCtr. Genotoxins Carcinogens Eval. Department of Pathology Botucatu School of Medicine, Botucatu, SP
dc.description.affiliationTOXICAN - Departamento de Patologia Faculdade Med. de Botucatu - UNESP
dc.description.affiliationUnespTOXICAN - Departamento de Patologia Faculdade Med. de Botucatu - UNESP
dc.format.extent593-596
dc.identifierhttp://dx.doi.org/10.1097/01.DON.0000121614.10075.A3
dc.identifier.citationJournal of Endodontics, v. 30, n. 8, p. 593-596, 2004.
dc.identifier.doi10.1097/01.DON.0000121614.10075.A3
dc.identifier.issn0099-2399
dc.identifier.lattes5051118752980903
dc.identifier.lattes7528116925519142
dc.identifier.scopus2-s2.0-4143135152
dc.identifier.urihttp://hdl.handle.net/11449/67816
dc.identifier.wosWOS:000222923700008
dc.language.isoeng
dc.relation.ispartofJournal of Endodontics
dc.relation.ispartofjcr2.886
dc.relation.ispartofsjr1,585
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectcalcium hydroxide
dc.subjectformocresol
dc.subjectphenol derivative
dc.subjectanimal cell
dc.subjectantibacterial activity
dc.subjectcomet assay
dc.subjectcontrolled study
dc.subjectdentistry
dc.subjectDNA damage
dc.subjectfibroblast
dc.subjectgenotoxicity
dc.subjecthuman
dc.subjecthuman cell
dc.subjectKruskal Wallis test
dc.subjectlymphoma cell
dc.subjectnonhuman
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectCalcium Hydroxide
dc.subjectCell Survival
dc.subjectCells, Cultured
dc.subjectChlorophenols
dc.subjectComet Assay
dc.subjectDNA Damage
dc.subjectFibroblasts
dc.subjectFormocresols
dc.subjectHumans
dc.subjectLymphoma
dc.subjectMice
dc.subjectMutagens
dc.subjectRoot Canal Irrigants
dc.subjectStatistics, Nonparametric
dc.subjectTumor Cells, Cultured
dc.titleLack of genotoxicity of formocresol, paramonochlorophenol, and calcium hydroxide on mammalian cells by comet assayen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes5051118752980903
unesp.author.lattes7528116925519142
unesp.author.orcid0000-0001-6947-5627[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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