Prenatal lipopolysaccharide exposure affects sexual dimorphism in different germlines of mice with a depressive phenotype

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dc.contributor.authorReis-Silva, Thiago M.
dc.contributor.authorCohn, Daniel W. H.
dc.contributor.authorSandini, Thaisa M.
dc.contributor.authorUdo, Mariana S. B.
dc.contributor.authorTeodorov, Elizabeth
dc.contributor.authorBernardi, Maria Martha [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T15:28:50Z
dc.date.available2018-11-26T15:28:50Z
dc.date.issued2016-03-15
dc.description.abstractThe objective of the present study was to investigate whether prenatal lipopolysaccharide (LPS) administration modifies the expression of depressive and non-depressive-like behavior inmale and female mice across two generations. The sexual dimorphism of these mice was also examined in the open-field test. Male and female mice of the parental (F0) generation were selected for depressive-or non-depressive-like behavioral profiles using the tail suspension test (TST). Animals with similar profiles were matched for further mating. On gestation day (GD) 15, pregnant F0 mice received LPS (100 mu g/kg, i.p.) and were allowed to nurture their offspring freely. Adult male and female of the F1 generation were then selected according to behavioral profiles and observed in the open field. Male and female mice of the two behavioral profiles were then mated to obtain the F2 generation. Adults from the F2 generation were also behaviorally phenotyped, and open field behavior was assessed. Male mice that were selected for depressive-and non-depressive-like behaviors and treated or not with LPS in the parental generation exhibited similar proportions of behavioral profiles in both filial lines, but LPS exposure increased the number of depressive-like behavior. An effect of gender was observed in the F1 and F2 generations, in which male mice were more sensitive to the intergenerational effects of LPS in the TST. These data indicate that prenatal LPS exposure on GD15 in the F0 generation influenced the transmission of depressive-and nondepressive-like behavior across filial lines, with sexual dimorphism between phenotypes. (C) 2016 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Dept Neurosci & Behav, Inst Psychol, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Vet Med, Neuroimmunomodulat Res Grp, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Vet Med, Dept Pathol, BR-05508 Sao Paulo, Brazil
dc.description.affiliationFed Univ ABC, Math Computat & Cognit Ctr, Santo andre, Brazil
dc.description.affiliationUniv Estadual Paulista, Postgrad Program Environm & Expt Pathol, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Postgrad Program Dent, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Postgrad Program Environm & Expt Pathol, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Postgrad Program Dent, Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPrograma Individual de pesquisa para docentes da Universidade Paulista
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdPrograma Individual de pesquisa para docentes da Universidade Paulista: UNIP-7-02915-2014
dc.description.sponsorshipIdFAPESP: 2013/03912-0
dc.description.sponsorshipIdFAPESP: 09/51886-3
dc.format.extent129-137
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2016.02.068
dc.identifier.citationLife Sciences. Oxford: Pergamon-elsevier Science Ltd, v. 149, p. 129-137, 2016.
dc.identifier.doi10.1016/j.lfs.2016.02.068
dc.identifier.fileWOS000371790100016.pdf
dc.identifier.issn0024-3205
dc.identifier.urihttp://hdl.handle.net/11449/158738
dc.identifier.wosWOS:000371790100016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLife Sciences
dc.relation.ispartofsjr1,071
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectEndotoxin
dc.subjectLipopolysaccharide
dc.subjectTail suspension test
dc.subjectPrenatal
dc.subjectGenerations
dc.titlePrenatal lipopolysaccharide exposure affects sexual dimorphism in different germlines of mice with a depressive phenotypeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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