Resveratrol Decreases Periodontal Breakdown and Modulates Local Levels of Cytokines During Periodontitis in Rats

dc.contributor.authorCasati, Marcio Z. [UNESP]
dc.contributor.authorAlgayer, Carolina [UNESP]
dc.contributor.authorCruz, Geisa Cardoso da [UNESP]
dc.contributor.authorRibeiro, Fernanda V. [UNESP]
dc.contributor.authorCasarin, Renato C. V. [UNESP]
dc.contributor.authorPimentel, Suzana P. [UNESP]
dc.contributor.authorCirano, Fabiano R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.abstractBackground: Resveratrol (3,49,5-trihydroxystilbene) is a naturally occurring product found in numerous plants. Among its biologic properties, resveratrol may promote immunomodulatory effects on the host response. This study investigates the effect of continuous administration of resveratrol on the progression of experimental periodontitis in rats.Methods: Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: 1) daily administration of the placebo solution (control group) or 2) 10 mg/kg resveratrol (RESV group). The therapies were administered systemically for 30 days: for 19 days before periodontitis induction and then for another 11 days. Then, the specimens were processed for morphometric analysis of bone loss, and the gingival tissue surrounding the first molar was collected for quantification of interleukin (IL)-1 beta, IL-4, and IL-17 using a multiplexing assay.Results: Intergroup comparisons of the morphometric outcomes revealed higher bone loss values in ligated molars and unligated teeth in the control group than the RESV group (P < 0.05). The immunoenzymatic assay of the gingival tissue showed a lower concentration of IL-17 in the RESV group than the control group (P < 0.05), whereas no differences in the IL-1 beta and IL-4 levels of the groups were observed (P > 0.05).Conclusions: Continuous administration of resveratrol may decrease periodontal breakdown induced experimentally in rats. In addition, lower levels of IL-17 were found in the RESV group. Future studies are important to confirm the mechanism through which resveratrol exerts its effects.en
dc.description.affiliationUniv Estadual Paulista, Sch Dent, Dent Res Div, BR-04026002 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Dent, Dent Res Div, BR-04026002 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipNational Counsel of Technological and Scientific Development
dc.description.sponsorshipIdFAPESP: 12/50487-0
dc.description.sponsorshipIdNational Counsel of Technological and Scientific Development303693/2009-6
dc.description.sponsorshipIdNational Counsel of Technological and Scientific Development118063/2012-0
dc.identifier.citationJournal Of Periodontology. Chicago: Amer Acad Periodontology, v. 84, n. 10, p. E58-E64, 2013.
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAlveolar bone lossen
dc.subjectanti-bacterial agentsen
dc.subjectanti-inflammatory agentsen
dc.subjectplants, medicinalen
dc.titleResveratrol Decreases Periodontal Breakdown and Modulates Local Levels of Cytokines During Periodontitis in Ratsen
dcterms.rightsHolderAmer Acad Periodontology[7]