Fluoride Exposure and Salivary Glands: How Is Glandular Morphology Susceptible to Long-Term Exposure? A Preclinical Study

dc.contributor.authorMatos-Sousa, José Mário
dc.contributor.authorBittencourt, Leonardo Oliveira
dc.contributor.authorFerreira, Maria Karolina Martins
dc.contributor.authordos Santos, Vinicius Ruan Neves
dc.contributor.authorBalbinot, Karolyny Martins
dc.contributor.authorAlves-Júnior, Sérgio
dc.contributor.authorPinheiro, João de Jesus Viana
dc.contributor.authorCharone, Senda
dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorLima, Rafael Rodrigues
dc.contributor.institutionUniversidade Federal do Pará (UFPA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T12:28:17Z
dc.date.available2023-07-29T12:28:17Z
dc.date.issued2022-09-01
dc.description.abstractDespite a strong body of evidence attesting to the effectiveness of fluoride (F) in preventing and controlling caries, some studies have sought to investigate the influence of F exposure on the salivary glands, organs that are essential for the maintenance of cavity homeostasis through salivary production, finding that exposure to F can cause biochemical and proteomic changes. Thus, this study aimed to investigate the morphological effects of prolonged exposure to F on the salivary glands of mice, at concentrations that would correspond to optimally fluoridated water (suitable for human consumption) and to fluorosis-endemic regions. Twenty-four male mice (Mus musculus) were divided into three groups, according to F levels in the drinking water: 0 (control), 10, or 50 mg F/L, with an exposure period of 60 days. The glands were morphometrically analyzed for the total acinar area, parenchyma area, and stromal area, as well as for the immunohistochemical analysis of myoepithelial cells. The results showed that prolonged exposure to F at 10 mg F/L did not promote significant changes in the morphometry of the salivary glands of mice, which reinforces the safety of the chronic use of F in low doses.en
dc.description.affiliationLaboratory of Functional and Structural Biology Institute of Biological Sciences Federal University of Pará, PA
dc.description.affiliationSchool of Dentistry Federal University of Pará, PA
dc.description.affiliationDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University, SP
dc.description.affiliationUnespDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University, SP
dc.identifierhttp://dx.doi.org/10.3390/jcm11185373
dc.identifier.citationJournal of Clinical Medicine, v. 11, n. 18, 2022.
dc.identifier.doi10.3390/jcm11185373
dc.identifier.issn2077-0383
dc.identifier.scopus2-s2.0-85138731695
dc.identifier.urihttp://hdl.handle.net/11449/245972
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Medicine
dc.sourceScopus
dc.subjectfluoride
dc.subjectsalivary glands
dc.subjectsodium fluoride
dc.titleFluoride Exposure and Salivary Glands: How Is Glandular Morphology Susceptible to Long-Term Exposure? A Preclinical Studyen
dc.typeArtigo
unesp.author.orcid0000-0001-7887-3811[4]
unesp.author.orcid0000-0002-6914-6441[7]
unesp.author.orcid0000-0002-1550-3933[9]
unesp.author.orcid0000-0003-1486-4013[10]

Arquivos

Coleções