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High expression of human monocyte iNOS mRNA induced by Paracoccidioides brasiliensis is not associated with increase in NO production

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dc.contributor.authorBordon-Graciani, Ana Paula [UNESP]
dc.contributor.authorDias-Melicio, Luciane Alarcao [UNESP]
dc.contributor.authorAcorci-Valerio, Michele Janegitz [UNESP]
dc.contributor.authorAraujo, Joao Pessoa [UNESP]
dc.contributor.authorSoares, Angela Maria Victoriano de Campos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:51:05Z
dc.date.available2014-05-20T13:51:05Z
dc.date.issued2012-10-01
dc.description.abstractIn this study we investigated the role of nitric oxide (NO) in monocyte fungicidal activity against Paracoccidioides brasiliensis. We found that cells primed with IFN-gamma, TNF-alpha or GM-CSF and challenged with a high-(Pb18) or low-virulence (Pb265) strain of the fungus increase their fungicidal activity. Expression of iNOS mRNA was increased after priming cells with each cytokine, and tended to be inhibited by Pb18. Despite up-regulation of iNOS mRNA expression by Pb265, an equivalent increase in NO production was not detected, as metabolite levels were similar in all cultures. The results indicated that high expression of human monocyte iNOS mRNA induced by P brasiliensis is not correlated with NO concentrations produced. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 São Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Med, Dept Patol, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Fac Med, Dept Patol, BR-18618970 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 05/55570-0
dc.format.extent1049-1053
dc.identifierhttp://dx.doi.org/10.1016/j.micinf.2012.07.009
dc.identifier.citationMicrobes and Infection. Amsterdam: Elsevier B.V., v. 14, n. 12, p. 1049-1053, 2012.
dc.identifier.doi10.1016/j.micinf.2012.07.009
dc.identifier.issn1286-4579
dc.identifier.urihttp://hdl.handle.net/11449/18242
dc.identifier.wosWOS:000309441800007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMicrobes and Infection
dc.relation.ispartofjcr2.924
dc.relation.ispartofsjr1,205
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHuman monocytesen
dc.subjectParacoccidioides brasiliensisen
dc.subjectNitric oxideen
dc.subjectiNOSen
dc.subjectFungicidal activityen
dc.subjectCytokinesen
dc.titleHigh expression of human monocyte iNOS mRNA induced by Paracoccidioides brasiliensis is not associated with increase in NO productionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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