Influence of Estrogen Deficiency on Bone Around Osseointegrated Dental Implants: An Experimental Study in the Rat Jaw Model

dc.contributor.authorGiro, Gabriela [UNESP]
dc.contributor.authorCoelho, Paulo G.
dc.contributor.authorSales-Pessoa, Roberto
dc.contributor.authorPereira, Rosa Maria Rodrigues
dc.contributor.authorKawai, Toshihisa
dc.contributor.authorOrrico, Silvana Regina Perez [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity College of Dentistry
dc.contributor.institutionInstituto de Pesquisa e Ensino em Saúde
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionThe Forsyth Institute
dc.description.abstractPurpose The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model. Materials and Methods This study used 16 female rats that had the first molars bilaterally extracted and were allowed to heal for 30 days before implant placement. Sixty days after implant placement, the animals were randomly subjected to sham surgery or ovariectomy (OVX). The animals were euthanized 90 days after OVX. Bone-to-implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers, and cells positive for tartrate-resistant acid phosphatase were assessed for the 2 groups. Results The results showed that OVX group presented a decrease of systemic bone density, alterations in bone turnover markers, and an increase of cells positive for tartrate-resistant acid phosphatase compared with the sham-surgery group. However, no difference relative to bone-to-implant contact and bone area fraction occupancy was observed between groups. Conclusions The findings of this study demonstrate that estrogen deficiency may not be considered a risk factor for osseointegrated implant failure in jaw bone.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Oral Diag & Surg, Araraquara Dent Sch, São Paulo, Brazil
dc.description.affiliationNYU, Coll Dent, Dept Periodontol & Implant Dent, New York, NY USA
dc.description.affiliationInst Pesquisa & Ensino Saude, Uberlandia, MG, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Bone Metab Lab, Div Rheumatol, São Paulo, Brazil
dc.description.affiliationForsyth Inst, Dept Immunol, Boston, MA USA
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNational Institute of Dental and Craniofacial Research
dc.description.sponsorshipIdFAPESP: 05/03737-8
dc.description.sponsorshipIdNIDCR: DE-018499
dc.description.sponsorshipIdNIDCR: DE-019917
dc.identifier.citationJournal of Oral and Maxillofacial Surgery. Philadelphia: W B Saunders Co-elsevier Inc, v. 69, n. 7, p. 1911-1918, 2011.
dc.publisherW B Saunders Co-elsevier Inc
dc.relation.ispartofJournal of Oral and Maxillofacial Surgery
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleInfluence of Estrogen Deficiency on Bone Around Osseointegrated Dental Implants: An Experimental Study in the Rat Jaw Modelen
dcterms.rightsHolderW B Saunders Co-elsevier Inc
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.departmentDiagnóstico e Cirurgiapt