Evaluation of osteoconduction of a synthetic hydroxyapatite/β-tricalcium phosphate block fixed in rabbit mandibles

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dc.contributor.authorPires, Luis Carlos de Almeida
dc.contributor.authorda Silva, Rodrigo Capalbo [UNESP]
dc.contributor.authorPoli, Pier Paolo
dc.contributor.authorEsgalha, Fernando Ruas
dc.contributor.authorHadad, Henrique [UNESP]
dc.contributor.authorPalin, Letícia Pitol [UNESP]
dc.contributor.authorSantos, Ana Flávia Piquera [UNESP]
dc.contributor.authorColombo, Luara Teixiera [UNESP]
dc.contributor.authorde Jesus, Laís Kawamata [UNESP]
dc.contributor.authorBassi, Ana Paula Farnezi [UNESP]
dc.contributor.authorMaiorana, Carlo
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.authorde Carvalho, Paulo Sérgio Perri
dc.contributor.authorSouza, Francisley Ávila [UNESP]
dc.contributor.institutionSão Leopoldo Mandic School of Dentistry and Research Center
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Milan
dc.date.accessioned2021-06-25T10:37:52Z
dc.date.available2021-06-25T10:37:52Z
dc.date.issued2020-11-01
dc.description.abstract(1) Background: This study aimed to evaluate the incorporation of hydroxyapatite/β-tricalcium phosphate blocks grafted in rabbit mandibles. (2) Methods: Topographic characterization of biomaterial was performed through scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDX). Ten rabbits randomly received autogenous bone graft harvested from the tibia (Autogenous Group—AG) or synthetic biomaterial manufactured in β-tricalcium phosphate (Biomaterial Group—BG) at their right and left mandibular angles. Euthanasia was performed at 30 and 60 postoperative days; (3) Results: SEM-EDX showed a surface with the formation of crystals clusters. Histological analyses in BG at 30 days showed a slower process of incorporation than AG. At 60 days, BG showed remnants of biomaterial enveloped by bone tissue in the anabolic modeling phase. Histometric analysis showed that mean values of newly formed bone-like tissue in the AG (6.56%/9.70%) were statistically higher compared to BG (3.14%/6.43%) in both periods, respectively. Immunohistochemical analysis demonstrated early bone formation and maturation in the AG with more intense osteopontin and osteocalcin staining. (4) Conclusions: The biomaterial proved to be a possible bone substitute, being incorporated into the receiving bed; however, it showed delayed bone incorporation compared to autogenous bone.en
dc.description.affiliationSão Leopoldo Mandic School of Dentistry and Research Center
dc.description.affiliationDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP
dc.description.affiliationImplant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCSS Cà Granda Ospedale Maggiore Policlinico University of Milan
dc.description.affiliationDepartment of Basic Science Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP
dc.description.affiliationUnespDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP
dc.description.affiliationUnespDepartment of Basic Science Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP
dc.format.extent1-16
dc.identifierhttp://dx.doi.org/10.3390/ma13214902
dc.identifier.citationMaterials, v. 13, n. 21, p. 1-16, 2020.
dc.identifier.doi10.3390/ma13214902
dc.identifier.issn1996-1944
dc.identifier.scopus2-s2.0-85094864275
dc.identifier.urihttp://hdl.handle.net/11449/206772
dc.language.isoeng
dc.relation.ispartofMaterials
dc.sourceScopus
dc.subjectBiocompatibility
dc.subjectBiomaterials
dc.subjectBone augmentation
dc.subjectBone conduction
dc.subjectBone grafting
dc.subjectCalcium hydroxyapatite
dc.subjectTissue regeneration
dc.titleEvaluation of osteoconduction of a synthetic hydroxyapatite/β-tricalcium phosphate block fixed in rabbit mandiblesen
dc.typeArtigo

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