A New Curcuminoids-Coumarin Derivative: Mechanochemical Synthesis, Characterization and Evaluation of Its In Vitro Cytotoxicity and Antimicrobial Properties

Página do item simplificado
dc.contributor.authorde Moura, Aniele [UNESP]
dc.contributor.authorGaglieri, Caroline [UNESP]
dc.contributor.authorAlarcon, Rafael Turra [UNESP]
dc.contributor.authorFerreira, Laura Teófilo [UNESP]
dc.contributor.authorVecchi, Rafael [UNESP]
dc.contributor.authorSanches, Mariana Liessa Rovis
dc.contributor.authorde Oliveira, Rodrigo Cardoso
dc.contributor.authorVenturini, James [UNESP]
dc.contributor.authorda Silva-Filho, Luiz Carlos [UNESP]
dc.contributor.authorJunior Caires, Flávio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.date.accessioned2022-04-29T08:46:04Z
dc.date.available2022-04-29T08:46:04Z
dc.date.issued2021-11-08
dc.description.abstractOver the years, several drugs have been developed deriving from plants to investigate possible therapeutic roles. Among them, curcuminoids and coumarins, which, display a wide range of biological activity against several strains. Therefore, it was synthesized a curcuminoids-coumarin derivative by a mechanochemical multicomponent reaction. By NMR and HRMS results confirmed the formation of a mixture of three curcuminoids-coumarin derivatives in the same sample. The Influence of time during the milling process was evaluated, resulting in a crystalline product in only 30 min. The LAG milling carried out with different solvents showed that the product is obtained regardless of the solvent polarity. Furthermore, the biological evaluation showed that the curcuminoids-coumarin derivative has better activity against S. aureus than curcumin and 4-hydroxycoumarin. Lastly, the cell viability study exhibited a decrease of cytotoxicity of the derivative, compared to curcumin, against NIH3T3 cells.en
dc.description.affiliationSchool of Sciences Chemistry Department UNESP São Paulo State University
dc.description.affiliationInstitute of Chemistry UNESP-São Paulo State University
dc.description.affiliationMedicine School Tropical Diseases and Imaging Diagnosis UNESP-São Paulo State University
dc.description.affiliationBauru School of Dentistry Department of Biological Sciences USP-University of São Paulo
dc.description.affiliationMedicine School UFMS- Mato Grosso do Sul Federal University
dc.description.affiliationUnespSchool of Sciences Chemistry Department UNESP São Paulo State University
dc.description.affiliationUnespInstitute of Chemistry UNESP-São Paulo State University
dc.description.affiliationUnespMedicine School Tropical Diseases and Imaging Diagnosis UNESP-São Paulo State University
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCAPES: 024/2012 Pro-equipment
dc.format.extent11352-11361
dc.identifierhttp://dx.doi.org/10.1002/slct.202103359
dc.identifier.citationChemistrySelect, v. 6, n. 41, p. 11352-11361, 2021.
dc.identifier.doi10.1002/slct.202103359
dc.identifier.issn2365-6549
dc.identifier.scopus2-s2.0-85118547294
dc.identifier.urihttp://hdl.handle.net/11449/231546
dc.language.isoeng
dc.relation.ispartofChemistrySelect
dc.sourceScopus
dc.subjectBiological activity
dc.subjectCurcuminoids
dc.subjectMechanochemistry
dc.subjectMulticomponent reactions
dc.subjectSustainable chemistry.
dc.titleA New Curcuminoids-Coumarin Derivative: Mechanochemical Synthesis, Characterization and Evaluation of Its In Vitro Cytotoxicity and Antimicrobial Propertiesen
dc.typeArtigo
unesp.author.orcid0000-0002-3475-6207[1]
unesp.author.orcid0000-0001-9612-6887[2]
unesp.author.orcid0000-0003-2798-9587[3]
unesp.author.orcid0000-0003-3187-2111[10]
unesp.departmentCiências Biológicas - FCpt

Arquivos

Coleções

Bauru - FC - Faculdade de Ciências