Cellulitis-related Rhodococcus equi in a cat harboring VAPA-type plasmid pattern

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dc.contributor.authorRocha, Brizza Zorayd Luz Lopes
dc.contributor.authorPortilho, Fábio Vinícius Ramos [UNESP]
dc.contributor.authorGarino Júnior, Felício
dc.contributor.authorMonti, Fabiana dos Santos
dc.contributor.authorde Almeida, Beatriz Oliveira [UNESP]
dc.contributor.authorde Souza, Adriana Aparecida Lopes [UNESP]
dc.contributor.authorMorizane, Yuri
dc.contributor.authorSakaizawa, Naho
dc.contributor.authorSuzuki, Yasunori
dc.contributor.authorKakuda, Tsutomu
dc.contributor.authorTakai, Shinji
dc.contributor.authorde Farias, Marconi Rodrigues
dc.contributor.authorRibeiro, Márcio Garcia [UNESP]
dc.contributor.institutionPet Center Cariri
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAnimal Vetlab
dc.contributor.institutionPontifícia Universidade Católica do Paraná – PUCPR
dc.contributor.institutionKitasato University
dc.date.accessioned2022-05-01T09:00:54Z
dc.date.available2022-05-01T09:00:54Z
dc.date.issued2021-11-01
dc.description.abstractRhodococcus equi is a well-known intracellular facultative bacterium that is opportunistic in nature, and a contagious disease-causing agent of pyogranulomatous infections in humans and multihost animals. Feline rhodococcosis is an uncommon or unnoticed clinical condition, in which the organism is usually refractory to conventional antimicrobial therapy. The pathogenicity of the agent is intimately associated with plasmid-governed infectivity, which is attributed to the presence of plasmid-encoded virulence-associated proteins (Vap). Three host-adapted virulence plasmid types (VAPs) have been distinguished to date: pVAPA, pVAPB, and pVAPN, whose infections are related to equine, pig, and bovine or caprine origin, respectively, while humans are infected by all three VAP types. Most virulence studies with R. equi plasmid types in animals involve livestock species. Conversely, data on the pathogenicity and human relevance of the virulence plasmid profile of R. equi isolated from cats remains unclear. This report describes a case of cellulitis-related R. equi that harbors the pVAPA-type in a cat with cutaneous lesion. Long-term therapy of the cat using marbofloxacin, a broad-spectrum third-generation fluoroquinolone, resulted effectiveness. pVAPA is a host-adapted virulent type that has been associated predominantly with pulmonary foal infections. Our cat had a history of contact with other cats, livestock (including horses), and farm environment that could have favored the transmission of the pathogen. Besides no clear evidence of cat-to-humans transmission of the pathogen, the identification of R. equi harboring pVAPA-type in a cat with cutaneous abscessed lesion represent relevance in human health because this virulent type has been described in people worldwide with clinical rhodococcal disorders.en
dc.description.affiliationVeterinary Clinic of Companion Animals Pet Center Cariri
dc.description.affiliationUNESP-São Paulo State University Department of Animal Production and Preventive Veterinary Medicine
dc.description.affiliationAnimal Vetlab
dc.description.affiliationGraduate Program in Animal Science School of Life Sciences Pontifícia Universidade Católica do Paraná – PUCPR
dc.description.affiliationKitasato University Department of Animal Hygiene
dc.description.affiliationUnespUNESP-São Paulo State University Department of Animal Production and Preventive Veterinary Medicine
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 310345/2020-0
dc.identifierhttp://dx.doi.org/10.1016/j.micpath.2021.105186
dc.identifier.citationMicrobial Pathogenesis, v. 160.
dc.identifier.doi10.1016/j.micpath.2021.105186
dc.identifier.issn1096-1208
dc.identifier.issn0882-4010
dc.identifier.scopus2-s2.0-85114719925
dc.identifier.urihttp://hdl.handle.net/11449/233521
dc.language.isoeng
dc.relation.ispartofMicrobial Pathogenesis
dc.sourceScopus
dc.subjectExtrapulmonary signs
dc.subjectFeline rhodococcosis
dc.subjectMALDI-TOF MS
dc.subjectPathogenicity
dc.subjectpVAPA-type
dc.subjectVirulence plasmid profile
dc.titleCellulitis-related Rhodococcus equi in a cat harboring VAPA-type plasmid patternen
dc.typeArtigo
unesp.author.orcid0000-0001-9278-0232[9]
unesp.author.orcid0000-0002-0951-2884[10]

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Artigos - Higiene Veterinária e Saúde Pública - FMVZ