Polydioxanone Membrane Compared with Collagen Membrane for Bone Regeneration

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dc.contributor.authorQuirino, Lilian Caldas [UNESP]
dc.contributor.authorde Azambuja Carvalho, Pedro Henrique [UNESP]
dc.contributor.authorNeto, Renato Torres Augusto [UNESP]
dc.contributor.authorComachio, Cássio Amaro [UNESP]
dc.contributor.authorMonteiro, Naara Gabriela [UNESP]
dc.contributor.authorErvolino-Silva, Ana Cláudia [UNESP]
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.authorPereira-Filho, Valfrido Antonio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:06:54Z
dc.date.available2023-07-29T16:06:54Z
dc.date.issued2023-02-01
dc.description.abstractGuided bone regeneration (GBR) is an approach that induces osteopromotion through the regenerative membranes. These barriers exhibit bioactive behavior and mechanical function. Polydioxanone is a synthetic option, already used in medicine and dentistry, with good results in bone regeneration. This study aimed to evaluate bone repair in critical defects in rat calvaria using a polydioxanone membrane (Plenum® Guide) compared with a commercially available collagen-based membrane (Bio-Gide®). The bone defects were filled with Plenum® Osshp, a synthetic bone graft, hydroxyapatite:β-tricalcium phosphate, 70:30%, Group PG (Plenum® Guide + Plenum® Osshp), and Group BG (Geistlich Bio-Gide® + Plenum® Osshp). The specimens were submitted to immunohistochemical (RUNX2 and OPN), gene expression (RUNX2, IBSP, and VEGF), histometric, and microtomography analyses after 07, 15, 30, and 60 days postoperative. PG group showed greater immunolabeling area for RUNX2 and OPN, higher gene expression of VEGF (3.15 ± 0.85), and IBSP (24.9 ± 0.59). However, there was no statistical difference between groups in the histometric analysis regarding the percentage of connective tissue PG (0.83 ± 0.45), BG (0.70 ± 0.34), neoformed bone PG (0.60 ± 0.4), BG (0.65 ± 0.51), and remaining biomaterial PG (0.84 ± 0.31), BG (0.91 ± 0.33). In addition, there was no statistical difference between groups by micro-CT analysis. The absorbable-synthetic membrane, Plenum® Guide, is an effective membrane for guided bone regeneration.en
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), Rua Humaitá 1680, SP
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP
dc.description.affiliationDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), Rua Humaitá 1680, SP
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP
dc.description.affiliationUnespDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP
dc.identifierhttp://dx.doi.org/10.3390/polym15040868
dc.identifier.citationPolymers, v. 15, n. 4, 2023.
dc.identifier.doi10.3390/polym15040868
dc.identifier.issn2073-4360
dc.identifier.scopus2-s2.0-85149031256
dc.identifier.urihttp://hdl.handle.net/11449/249703
dc.language.isoeng
dc.relation.ispartofPolymers
dc.sourceScopus
dc.subjectbone regeneration
dc.subjectmembrane
dc.subjectpolydioxanone
dc.subjectsynthetic polymer
dc.titlePolydioxanone Membrane Compared with Collagen Membrane for Bone Regenerationen
dc.typeArtigo
unesp.author.orcid0000-0003-2670-7998[2]
unesp.author.orcid0000-0001-5206-8291[3]
unesp.author.orcid0000-0002-2857-9195[5]
unesp.author.orcid0000-0002-6773-6966[7]
unesp.author.orcid0000-0001-8736-7507[8]

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