Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle

dc.contributor.authorCamargo, Gregório Miguel Ferreira de [UNESP]
dc.contributor.authorPorto-Neto, Laercio Ribeiro
dc.contributor.authorKelly, Matthew J.
dc.contributor.authorBunch, Rowan J.
dc.contributor.authorMcWilliam, Sean M.
dc.contributor.authorTonhati, Humberto [UNESP]
dc.contributor.authorLehnert, Sigrid A.
dc.contributor.authorFortes, Marina R. S.
dc.contributor.authorMoore, Stephen S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCommonwealth Scientific and Industrial Research Organization (CSIRO)
dc.contributor.institutionThe University of Queensland
dc.description.abstractBackground: Previous genome-wide association analyses identified QTL regions in the X chromosome for percentage of normal sperm and scrotal circumference in Brahman and Tropical Composite cattle. These traits are important to be studied because they are indicators of male fertility and are correlated with female sexual precocity and reproductive longevity. The aim was to investigate candidate genes in these regions and to identify putative causative mutations that influence these traits. In addition, we tested the identified mutations for female fertility and growth traits.Results: Using a combination of bioinformatics and molecular assay technology, twelve non-synonymous SNPs in eleven genes were genotyped in a cattle population. Three and nine SNPs explained more than 1% of the additive genetic variance for percentage of normal sperm and scrotal circumference, respectively. The SNPs that had a major influence in percentage of normal sperm were mapped to LOC100138021 and TAF7L genes; and in TEX11 and AR genes for scrotal circumference. One SNP in TEX11 was explained similar to 13% of the additive genetic variance for scrotal circumference at 12 months. The tested SNP were also associated with weight measurements, but not with female fertility traits.Conclusions: The strong association of SNPs located in X chromosome genes with male fertility traits validates the QTL. The implicated genes became good candidates to be used for genetic evaluation, without detrimentally influencing female fertility traits.en
dc.description.affiliationThe University of Queensland, School of Chemistry and Molecular Bioscience
dc.description.affiliationThe University of Queensland, Queensland Alliance for Agriculture and Food Innovation, Centre for Animal Science
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/12851-5
dc.identifier.citationBmc Genomics. London: Biomed Central Ltd, v. 16, p. 1-10, 2015.
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Genomics
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectNon-synonymous SNPen
dc.subjectX chromosomeen
dc.subjectBos taurus indicusen
dc.subjectScrotal circumferenceen
dc.subjectSperm morphologyen
dc.titleNon-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattleen
dcterms.rightsHolderBiomed Central Ltd[8][2][6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
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