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Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis

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dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authorBueno, J. P. [UNESP]
dc.contributor.authorAparecida Shikanai-Yasuda, M. [UNESP]
dc.contributor.authorFerreira, A. W. [UNESP]
dc.contributor.authorMasuda, A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T07:35:52Z
dc.date.available2014-05-27T07:35:52Z
dc.date.issued1989-12-09
dc.description.abstractThe 43,000-molecular-weight (43K) soluble glycoprotein was detected in sera of patients with paracoccidioidomycosis by the immunoblot technique by using as the probe rabbit monospecific antisera to this fraction. The 43K antigen was present before treatment in sera of patients with the acute (juvenile) form; it started to disappear from circulation after 10 months of chemotherapy, and it was undetectable afer 2 years of treatment. In the chronic cases, the 43K antigen was detected in patients without treatment, and it was absent in the healed cases. The detection of the 43K protein specific to Paracoccidioides brasiliensis may be important for its diagnostic value as well as for modulation of the host immune response.en
dc.description.affiliationDep. de Analises Clinicas Fac. de Ciencias Farmaceut. UNESP, Araraquara
dc.description.affiliationUnespDep. de Analises Clinicas Fac. de Ciencias Farmaceut. UNESP, Araraquara
dc.format.extent2842-2845
dc.identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC267138/
dc.identifier.citationJournal of Clinical Microbiology, v. 27, n. 12, p. 2842-2845, 1989.
dc.identifier.file2-s2.0-0024354515.pdf
dc.identifier.issn0095-1137
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.scopus2-s2.0-0024354515
dc.identifier.urihttp://hdl.handle.net/11449/63952
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Microbiology
dc.relation.ispartofjcr4.054
dc.relation.ispartofsjr2,256
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectfungus antigen
dc.subjectglycoprotein
dc.subjectimmunoglobulin g
dc.subjectclinical article
dc.subjectfungus
dc.subjecthuman
dc.subjecthuman cell
dc.subjectimmunoblotting
dc.subjectnonhuman
dc.subjectparacoccidioides brasiliensis
dc.subjectpriority journal
dc.subjectserum
dc.subjectsouth american blastomycosis
dc.subjectAntigens, Fungal
dc.subjectChromatography, Affinity
dc.subjectElectrophoresis, Polyacrylamide Gel
dc.subjectGlycoproteins
dc.subjectHuman
dc.subjectImmune Sera
dc.subjectImmunoblotting
dc.subjectMitosporic Fungi
dc.subjectMolecular Weight
dc.subjectParacoccidioides
dc.subjectParacoccidioidomycosis
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTime Factors
dc.subjectFungi
dc.subjectOryctolagus cuniculus
dc.subjectParacoccidioides brasiliensis
dc.titleDetection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosisen
dc.typeArtigo
unesp.author.orcid0000-0002-8059-0826[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas