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Cellular changes in the prostatic stroma of glucocorticoid-treated rats

dc.contributor.authorRibeiro, D. L.
dc.contributor.authorRafacho, A.
dc.contributor.authorBosqueiro, José Roberto [UNESP]
dc.contributor.authorTaboga, S. R. [UNESP]
dc.contributor.authorGoes, R. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T14:00:52Z
dc.date.available2014-05-20T14:00:52Z
dc.date.issued2008-06-01
dc.description.abstractGlucocorticoid hormones (GCs) have been widely used for the treatment of prostate cancer because of their inhibitory property against tumour growth. However, their mechanism of action in the prostate has received little attention. Excess GCs can lead to peripheral insulin resistance resulting in hyperglycaemia and hyperinsulinaemia. Insulin plays an important role as a cellular stimulant and high levels are related to low levels of androgens. Our objective has been to describe the effects of insulin resistance induced by dexamethasone treatment on the morphology of rat ventral prostate. Mate adult Wistar rats received daily intraperitoneal injections of dexamethasone or saline for five consecutive days after which the rats were killed and the ventral prostate was removed, weighed and prepared for conventional and transmission electron microscopy (TEM). Dexamethasone treatment resulted in atrophy and decreased proliferative activity of prostatic epithelial cells. TEM analysis revealed changes in the epithelium-stroma interface, with some interruptions in the basement membrane. Fibroblasts showed a secretory phenotype with dilated endoplasmic reticulum. Smooth muscle cells exhibited a contractile pattern with 50% atrophy, an irregular membrane and twisted nuclei. Mitochondrial alterations, such as enlarged size and high electron density in the mitochondrial matrix, were also detected in smooth muscle cells. Insulin resistance induced by dexamethasone is thus associated with epithelial atrophy similar to that described for diabetic rats. However, GCs are responsible for morphological changes in the stromal cell population suggesting the activation of fibroblasts and atrophy of the smooth muscle cells.en
dc.description.affiliationUniv Estadual Paulista, Dept Biol, BR-15054000 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Cell Biol, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Phys & Biophys, Campinas, SP, Brazil
dc.description.affiliationUNESP, Dept Phys Educ, Bauru, Brazil
dc.description.affiliationUNESP, Dept Biol, Sao Jose do Rio Preto, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biol, BR-15054000 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Dept Phys Educ, Bauru, Brazil
dc.description.affiliationUnespUNESP, Dept Biol, Sao Jose do Rio Preto, Brazil
dc.format.extent499-508
dc.identifierhttp://dx.doi.org/10.1007/s00441-008-0581-0
dc.identifier.citationCell and Tissue Research. New York: Springer, v. 332, n. 3, p. 499-508, 2008.
dc.identifier.doi10.1007/s00441-008-0581-0
dc.identifier.issn0302-766X
dc.identifier.lattes1445259468526188
dc.identifier.lattes0947193347312157
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0002-3622-460X
dc.identifier.urihttp://hdl.handle.net/11449/21504
dc.identifier.wosWOS:000256354500012
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCell and Tissue Research
dc.relation.ispartofjcr3.043
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectProstateen
dc.subjectinsulin resistanceen
dc.subjectGlucocorticoiden
dc.subjectstromaen
dc.subjectSmooth muscle cellsen
dc.subjectRat (Wistar)en
dc.titleCellular changes in the prostatic stroma of glucocorticoid-treated ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes1445259468526188
unesp.author.lattes0947193347312157[5]
unesp.author.orcid0000-0002-0970-4288[4]
unesp.author.orcid0000-0002-3622-460X[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentEducação Física - FCpt
unesp.departmentBiologia - IBILCEpt

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