Optimization of (–)-cubebin biotransformation to (–)-hinokinin by the marine fungus Absidia coerulea 3A9
dc.contributor.author | de Souza, Jonathan Messias | |
dc.contributor.author | Santos, Mario Ferreira Conceição | |
dc.contributor.author | Pedroso, Rita Cassia Nascimento | |
dc.contributor.author | Pimenta, Leticia Pereira | |
dc.contributor.author | Siqueira, Kátia Aparecida | |
dc.contributor.author | Soares, Marcos Antonio | |
dc.contributor.author | Dias, Gustavo Muniz | |
dc.contributor.author | Pietro, Rosemeire Cristina Linhari Rodrigues [UNESP] | |
dc.contributor.author | Ramos, Henrique Pereira | |
dc.contributor.author | Silva, Marcio Luis Andrade | |
dc.contributor.author | Pauletti, Patricia Mendonça | |
dc.contributor.author | Veneziani, Rodrigo Cassio Sola | |
dc.contributor.author | Ambrósio, Sérgio Ricardo | |
dc.contributor.author | Braun, Glaucia Hollaender | |
dc.contributor.author | Januário, Ana Helena | |
dc.contributor.institution | University of Franca | |
dc.contributor.institution | Federal University of Mato Grosso | |
dc.contributor.institution | Federal University of ABC | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.date.accessioned | 2022-04-29T08:29:33Z | |
dc.date.available | 2022-04-29T08:29:33Z | |
dc.date.issued | 2021-09-01 | |
dc.description.abstract | The genus Absidia is widely used in the biotransformation of different classes of natural products. This study evaluates the ability of the Absidia coerulea 3A9 marine derived strain isolated from the ascidian Distaplia stilyfera to perform biotransformations by conducting assays with (–)-cubebin, as substrate. The experiment was optimized using the experimental design proposed by Plackett–Burman for seven factors and eight experiments, to establish the biotransformation conditions that would allow maximum production of biotransformed dibenzylbutyrolactone (–)-hinokinin. An analytical method based on Reverse-Phase-High Performance Liquid Chromatography (RP-HPLC) was developed to quantify the fungal biotransformation product. The factor that influenced the (–)-hinokinin peak area the most positively was the percentage of seawater (%seawater) given that its %relative standard deviation (%RSD) showed a 32.92% deviation from the real value. | en |
dc.description.affiliation | Center for Research in Exact and Technological Sciences University of Franca | |
dc.description.affiliation | Department of Botany and Ecology Biosciences Institute Federal University of Mato Grosso | |
dc.description.affiliation | Center for Natural and Human Sciences Federal University of ABC | |
dc.description.affiliation | Department of Drugs and Medicines School of Pharmaceutical Sciences University Estadual Paulista | |
dc.description.affiliationUnesp | Department of Drugs and Medicines School of Pharmaceutical Sciences University Estadual Paulista | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorshipId | CAPES: 001 | |
dc.description.sponsorshipId | FAPESP: 2014/19184-7 | |
dc.description.sponsorshipId | FAPESP: 2017/14261-1 | |
dc.description.sponsorshipId | CAPES: 23038.009588/2013-68 CSF-PVEs 27/2014 | |
dc.description.sponsorshipId | CNPq: 302340/2018-1 | |
dc.format.extent | 4313-4318 | |
dc.identifier | http://dx.doi.org/10.1007/s00203-021-02417-0 | |
dc.identifier.citation | Archives of Microbiology, v. 203, n. 7, p. 4313-4318, 2021. | |
dc.identifier.doi | 10.1007/s00203-021-02417-0 | |
dc.identifier.issn | 1432-072X | |
dc.identifier.issn | 0302-8933 | |
dc.identifier.scopus | 2-s2.0-85107470478 | |
dc.identifier.uri | http://hdl.handle.net/11449/228957 | |
dc.language.iso | eng | |
dc.relation.ispartof | Archives of Microbiology | |
dc.source | Scopus | |
dc.subject | (–)-hinokinin | |
dc.subject | Absidia coerulea | |
dc.subject | Ascidian | |
dc.subject | Distaplia stilyfera | |
dc.subject | Marine fungi | |
dc.subject | Plackett–Burman | |
dc.title | Optimization of (–)-cubebin biotransformation to (–)-hinokinin by the marine fungus Absidia coerulea 3A9 | en |
dc.type | Artigo | |
unesp.author.orcid | 0000-0002-6525-1738[1] | |
unesp.author.orcid | 0000-0003-1981-834X[2] | |
unesp.author.orcid | 0000-0001-7169-7720[3] | |
unesp.author.orcid | 0000-0003-0074-3034[4] | |
unesp.author.orcid | 0000-0002-4765-0487[5] | |
unesp.author.orcid | 0000-0002-8938-3188[6] | |
unesp.author.orcid | 0000-0003-2180-6399[7] | |
unesp.author.orcid | 0000-0001-7859-8127[8] | |
unesp.author.orcid | 0000-0001-6629-3641[9] | |
unesp.author.orcid | 0000-0002-9442-4757[10] | |
unesp.author.orcid | 0000-0003-1831-0050[11] | |
unesp.author.orcid | 0000-0001-7057-9706[12] | |
unesp.author.orcid | 0000-0001-5032-3930[13] | |
unesp.author.orcid | 0000-0002-1677-5332[14] | |
unesp.author.orcid | 0000-0002-3815-6903[15] | |
unesp.department | Fármacos e Medicamentos - FCF | pt |