Optimization of (–)-cubebin biotransformation to (–)-hinokinin by the marine fungus Absidia coerulea 3A9

dc.contributor.authorde Souza, Jonathan Messias
dc.contributor.authorSantos, Mario Ferreira Conceição
dc.contributor.authorPedroso, Rita Cassia Nascimento
dc.contributor.authorPimenta, Leticia Pereira
dc.contributor.authorSiqueira, Kátia Aparecida
dc.contributor.authorSoares, Marcos Antonio
dc.contributor.authorDias, Gustavo Muniz
dc.contributor.authorPietro, Rosemeire Cristina Linhari Rodrigues [UNESP]
dc.contributor.authorRamos, Henrique Pereira
dc.contributor.authorSilva, Marcio Luis Andrade
dc.contributor.authorPauletti, Patricia Mendonça
dc.contributor.authorVeneziani, Rodrigo Cassio Sola
dc.contributor.authorAmbrósio, Sérgio Ricardo
dc.contributor.authorBraun, Glaucia Hollaender
dc.contributor.authorJanuário, Ana Helena
dc.contributor.institutionUniversity of Franca
dc.contributor.institutionFederal University of Mato Grosso
dc.contributor.institutionFederal University of ABC
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:29:33Z
dc.date.available2022-04-29T08:29:33Z
dc.date.issued2021-09-01
dc.description.abstractThe genus Absidia is widely used in the biotransformation of different classes of natural products. This study evaluates the ability of the Absidia coerulea 3A9 marine derived strain isolated from the ascidian Distaplia stilyfera to perform biotransformations by conducting assays with (–)-cubebin, as substrate. The experiment was optimized using the experimental design proposed by Plackett–Burman for seven factors and eight experiments, to establish the biotransformation conditions that would allow maximum production of biotransformed dibenzylbutyrolactone (–)-hinokinin. An analytical method based on Reverse-Phase-High Performance Liquid Chromatography (RP-HPLC) was developed to quantify the fungal biotransformation product. The factor that influenced the (–)-hinokinin peak area the most positively was the percentage of seawater (%seawater) given that its %relative standard deviation (%RSD) showed a 32.92% deviation from the real value.en
dc.description.affiliationCenter for Research in Exact and Technological Sciences University of Franca
dc.description.affiliationDepartment of Botany and Ecology Biosciences Institute Federal University of Mato Grosso
dc.description.affiliationCenter for Natural and Human Sciences Federal University of ABC
dc.description.affiliationDepartment of Drugs and Medicines School of Pharmaceutical Sciences University Estadual Paulista
dc.description.affiliationUnespDepartment of Drugs and Medicines School of Pharmaceutical Sciences University Estadual Paulista
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2014/19184-7
dc.description.sponsorshipIdFAPESP: 2017/14261-1
dc.description.sponsorshipIdCAPES: 23038.009588/2013-68 CSF-PVEs 27/2014
dc.description.sponsorshipIdCNPq: 302340/2018-1
dc.format.extent4313-4318
dc.identifierhttp://dx.doi.org/10.1007/s00203-021-02417-0
dc.identifier.citationArchives of Microbiology, v. 203, n. 7, p. 4313-4318, 2021.
dc.identifier.doi10.1007/s00203-021-02417-0
dc.identifier.issn1432-072X
dc.identifier.issn0302-8933
dc.identifier.scopus2-s2.0-85107470478
dc.identifier.urihttp://hdl.handle.net/11449/228957
dc.language.isoeng
dc.relation.ispartofArchives of Microbiology
dc.sourceScopus
dc.subject(–)-hinokinin
dc.subjectAbsidia coerulea
dc.subjectAscidian
dc.subjectDistaplia stilyfera
dc.subjectMarine fungi
dc.subjectPlackett–Burman
dc.titleOptimization of (–)-cubebin biotransformation to (–)-hinokinin by the marine fungus Absidia coerulea 3A9en
dc.typeArtigo
unesp.author.orcid0000-0002-6525-1738[1]
unesp.author.orcid0000-0003-1981-834X[2]
unesp.author.orcid0000-0001-7169-7720[3]
unesp.author.orcid0000-0003-0074-3034[4]
unesp.author.orcid0000-0002-4765-0487[5]
unesp.author.orcid0000-0002-8938-3188[6]
unesp.author.orcid0000-0003-2180-6399[7]
unesp.author.orcid0000-0001-7859-8127[8]
unesp.author.orcid0000-0001-6629-3641[9]
unesp.author.orcid0000-0002-9442-4757[10]
unesp.author.orcid0000-0003-1831-0050[11]
unesp.author.orcid0000-0001-7057-9706[12]
unesp.author.orcid0000-0001-5032-3930[13]
unesp.author.orcid0000-0002-1677-5332[14]
unesp.author.orcid0000-0002-3815-6903[15]
unesp.departmentFármacos e Medicamentos - FCFpt

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