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NF-kappa B signaling modulation by EBV and KSHV

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dc.contributor.authorOliveira, Deilson Elgui de [UNESP]
dc.contributor.authorBallon, Gianna
dc.contributor.authorCesarman, Ethel
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionWeill Cornell Med Coll
dc.date.accessioned2014-05-20T13:37:31Z
dc.date.available2014-05-20T13:37:31Z
dc.date.issued2010-06-01
dc.description.abstractThe nuclear factor (NF)-kappa B signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gamma-herpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappa B signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappa B modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.en
dc.description.affiliationSão Paulo State Univ UNESP, Botucatu Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationWeill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USA
dc.description.affiliationUnespSão Paulo State Univ UNESP, Botucatu Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipDEO at Weill Medical College of Cornell University
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipSão Paulo State University (UNESP)
dc.description.sponsorshipSão Paulo Brazil
dc.description.sponsorshipNational Cancer Institute of the National Institutes of Health
dc.description.sponsorshipStarr Cancer Consortium
dc.description.sponsorshipIdCNPq: 200117/2008-4
dc.format.extent248-257
dc.identifierhttp://dx.doi.org/10.1016/j.tim.2010.04.001
dc.identifier.citationTrends In Microbiology. London: Elsevier B.V. London, v. 18, n. 6, p. 248-257, 2010.
dc.identifier.doi10.1016/j.tim.2010.04.001
dc.identifier.issn0966-842X
dc.identifier.lattes5240998569868081
dc.identifier.urihttp://hdl.handle.net/11449/12990
dc.identifier.wosWOS:000279090000004
dc.language.isoeng
dc.publisherElsevier B.V. London
dc.relation.ispartofTrends In Microbiology
dc.relation.ispartofjcr11.776
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleNF-kappa B signaling modulation by EBV and KSHVen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V. London
dspace.entity.typePublication
unesp.author.lattes5240998569868081
unesp.author.orcid0000-0001-5562-9648[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentPatologia - FMBpt

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Botucatu - FMB - Faculdade de Medicina