Off-label use of bone morphogenetic protein 2 in the reconstructions of mandibular continuity defects
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Oliveira, Marina Reis [UNESP]
De Oliveira Gorla, Luíz Fernando [UNESP]
Gabrielli, Marisa Aparecida Cabrini [UNESP]
Pereira-Filho, Valfrido Antonio [UNESP]
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This paper describes 3 patients of off-label use of bone morphogenetic protein 2 (rhBMP-2) in the reconstruction of mandibular continuity defects. In the first patient, rhBMP-2 was associated with iliac crest bone graft for late mandibular reconstruction after resection of osteosarcoma. In the 2 other patients, rhBMP-2 was used alone. In 1 patient the mandibular continuity defect was due to resection for treatment of osteomyelitis and in the other patient a continuity defect was created by unsuccessful osteogenic distraction for correction of mandibular hypoplasia. Despite the good results in those patients, the off-label use of rhBMP-2 is associated with increased rate of complications, so more studies are needed to assess the predictability of the use of rhBMP-2 in mandibular continuity defects. Therefore, at the moment the offlabel use of rhBMP-2 should be restricted to complicated bone defects in which the conventional alternatives of reconstruction were unsuccessful.
Bone morphogenetic protein 2 (rhBMP-2), Bone regeneration, Bone repair, Mandibular continuity defect
Journal of Craniofacial Surgery, v. 28, n. 1, p. 227-230, 2017.