Anti-Inflammatory Effects of Low-Level Light Emitting Diode Therapy on Achilles Tendinitis in Rats

dc.contributor.authorXavier, Murilo
dc.contributor.authorDavid, Debora Rodrigues
dc.contributor.authorde Souza, Renato Aparecido
dc.contributor.authorArrieiro, Arthur Nascimento
dc.contributor.authorMiranda, Humberto
dc.contributor.authorSantana, Eduardo Tadeu
dc.contributor.authorSilva, Jose Antonio
dc.contributor.authorCastillo Salgado, Miguel Angel [UNESP]
dc.contributor.authorAimbire, Flavio
dc.contributor.authorAlbertini, Regiane
dc.contributor.institutionVale Paraiba Univ
dc.contributor.institutionUniv Fed Vales Jequitinhonha & Mucuri
dc.contributor.institutionUniversidade Nove de Julho (UNINOVE)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Camilo Castelo Branco
dc.date.accessioned2014-05-20T14:04:41Z
dc.date.available2014-05-20T14:04:41Z
dc.date.issued2010-08-01
dc.description.abstractBackground and Objectives: The present study investigated the effects of low-level light emitting diode (LED) therapy (880 +/- 10 nm) on inflammatory process in a experimental model of Achilles tendinitis induced by collagenase.Study Design/Materials and Methods: Fifty-six male Wistar were separated into seven groups (n = 8), three groups in the experimental period of 7 days and four groups in the experimental period of 14 days, the control group (CONT), tendinitis group (TEND), LED therapy group (LEDT) for both experimental periods, and LED therapy group 7th to 14th day (LEDT delay) for 14 days experimental period. The LED parameters was 22 mW CW of optical output power, distributed in an irradiation area of 0.5 cm(2), with an irradiation time of 170 seconds, the applied energy density was 7.5 J/cm(2) in contact. The therapy was initiated 12 hours after the tendinitis induction, with a 48-hour interval between the irradiations. The histological analysis and inflammatory mediators were quantifiedResults: Our results showed that LED decreases the inflammatory cells influx and mRNA expression to IL-1 beta, IL-6, tumor necrosis factor-alpha (TNF-alpha) in both phase, and cyclooxygenase-2 (COX-2) just in initial phase (P < 0 05).Conclusion: Our results suggest that the anti-inflammatory therapy with low-power LED (880 nm) enhanced the tissue response in all groups We can conclude that the LED was able to reduce signs of inflammation in collagenase-induced tendinitis in rats by reducing the number of inflammatory cells and decrease mRNA expression of cytokines Lasers Surg. Med. 42:553-558, 2010 (C) 2010 Wiley-Liss, Inc.en
dc.description.affiliationVale Paraiba Univ, Inst Res & Dev, IP&D, BR-12244000 São Paulo, Brazil
dc.description.affiliationUniv Fed Vales Jequitinhonha & Mucuri, Dept Phys Therapy, BR-39100000 Diamantina, MG, Brazil
dc.description.affiliationCtr Univ Nove de Julho, Dept Ciencias Reabilitacao, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Odontol, São Paulo, Brazil
dc.description.affiliationUniv Camilo Castelo Branco, BR-116 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/02596-7
dc.format.extent553-558
dc.identifierhttp://dx.doi.org/10.1002/lsm.20896
dc.identifier.citationLasers In Surgery and Medicine. Hoboken: Wiley-liss, v. 42, n. 6, p. 553-558, 2010.
dc.identifier.doi10.1002/lsm.20896
dc.identifier.issn0196-8092
dc.identifier.lattes8235700830441386
dc.identifier.urihttp://hdl.handle.net/11449/22698
dc.identifier.wosWOS:000281009400014
dc.language.isoeng
dc.publisherWiley-liss
dc.relation.ispartofLasers In Surgery and Medicine
dc.relation.ispartofjcr2.726
dc.relation.ispartofsjr0,926
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcalcaneous tendonen
dc.subjecthistological analysisen
dc.subjectmRNAen
dc.subjectRT-PCRen
dc.subjectinflammatory mediatorsen
dc.titleAnti-Inflammatory Effects of Low-Level Light Emitting Diode Therapy on Achilles Tendinitis in Ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-liss
unesp.author.lattes8235700830441386
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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