Screen-Printed Electrodes on Tyvek Substrate as Low-Cost Device to Applications in Alzheimer's Disease Detection

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dc.contributor.authorPalley, Bianca Fortes
dc.contributor.authorArtur, Julio Cesar
dc.contributor.authorDe Arruda, Milena Nakagawa
dc.contributor.authorDe Souza, Gustavo Freitas
dc.contributor.authorGraves, David Alexandro
dc.contributor.authorBovolato, Ana Lívia De Carvalho [UNESP]
dc.contributor.authorDeffune, Elenice [UNESP]
dc.contributor.authorSchelp, Arthur Oscar [UNESP]
dc.contributor.authorGonçalves, Emerson Sarmento
dc.contributor.authorDe Moraes, Marli Leite
dc.contributor.institutionInstituto Tecnológico de Aeronaútica
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Do Vale Do Paraíba
dc.contributor.institutionInstituto de Aeronáutica e Espaço
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-05-01T15:46:14Z
dc.date.available2022-05-01T15:46:14Z
dc.date.issued2022-03-01
dc.description.abstractAlzheimer's disease (AD) is a progressive neurodegenerative disease characterized by impairment of cognitive functions and memory deterioration, which requires an early diagnosis for effective treatment. The use of immunosensors to detect Alzheimer s disease biomarkers stand out as a quick and cheap alternative for early detection of the disease. The development of Screen-Printed Electrodes (SPEs) meets a growing demand in the market for applications such as signal transducers in biosensor devices. In this work was development a method for fabrication of low cost SPE for application in the detection of Alzheimer s disease through autoantibodies. It was produced microelectrodes on polyvinyl chloride (PVC), polyvinylidene fluoride (PVDF) and high-density polyethylene (HDPE) manufactured by DuPont Tyvek®substrates. SPEs produced on Tyvek®substrates have shown promising results for low-cost, disposable and flexible sensors. The carbon paste showed excellent adhesion to Tyvek®substrate and the electrodes produced showed an electrochemical performance comparable to commercial electrodes, besides reproducible. The detection results showed that it is possible to detect anti-Aβ40 autoantibodies in real samples of serum and cerebrospinal fluid using the electrode modified with two bilayers of (PEI/(DDPG + Aβ40)) since the capacitance increased more in positive sample with the presence of autoantibody than in negative samples.en
dc.description.affiliationInstituto Tecnológico de Aeronaútica, SP
dc.description.affiliationUniversidade Federal de São Paulo Instituto de Ciência e Tecnologia, SP
dc.description.affiliationUniversidade Do Vale Do Paraíba, SP
dc.description.affiliationInstituto de Aeronáutica e Espaço, SP
dc.description.affiliationUniversidade Estadual Paulista Hemocentro de Botucatu, SP
dc.description.affiliationUnespUniversidade Estadual Paulista Hemocentro de Botucatu, SP
dc.identifierhttp://dx.doi.org/10.1149/1945-7111/ac584f
dc.identifier.citationJournal of the Electrochemical Society, v. 169, n. 3, 2022.
dc.identifier.doi10.1149/1945-7111/ac584f
dc.identifier.issn1945-7111
dc.identifier.issn0013-4651
dc.identifier.scopus2-s2.0-85126679278
dc.identifier.urihttp://hdl.handle.net/11449/234291
dc.language.isoeng
dc.relation.ispartofJournal of the Electrochemical Society
dc.sourceScopus
dc.titleScreen-Printed Electrodes on Tyvek Substrate as Low-Cost Device to Applications in Alzheimer's Disease Detectionen
dc.typeArtigo
unesp.author.orcid0000-0002-4800-3513[1]
unesp.author.orcid0000-0002-9789-0315[2]
unesp.author.orcid0000-0003-0333-5706[3]
unesp.author.orcid0000-0002-7673-8883 0000-0002-7673-8883[4]
unesp.author.orcid0000-0001-7387-8576[5]
unesp.author.orcid0000-0003-0245-122X[6]
unesp.author.orcid0000-0001-5928-7497[8]
unesp.author.orcid0000-0002-6511-5365 0000-0002-6511-5365[9]
unesp.author.orcid0000-0003-0213-3686[10]

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Artigos - Urologia - FMB
Artigos - Neurologia, Psicologia e Psiquiatria - FMB