Periodontal Disease Decreases Insulin Sensitivity and Insulin Signaling

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dc.contributor.authorColombo, Natalia H. [UNESP]
dc.contributor.authorShirakashi, Daisy J. [UNESP]
dc.contributor.authorChiba, Fernando Y. [UNESP]
dc.contributor.authorde Lima Coutinho, Maria Sara [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorGarbin, Clea Adas Saliba [UNESP]
dc.contributor.authorMachado, Ubiratan Fabres [UNESP]
dc.contributor.authorSumida, Doris Hissako [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:30:29Z
dc.date.accessioned2014-05-20T13:42:58Z
dc.date.available2013-09-30T18:30:29Z
dc.date.available2014-05-20T13:42:58Z
dc.date.issued2012-07-01
dc.description.abstractBackground: The purpose of this study is to investigate whether local inflammatory events, such as periodontal disease, are able to increase tumor necrosis factor-alpha (TNF-alpha) plasmatic concentration and decrease insulin sensitivity and insulin signaling in non-diabetic rats.Methods: Forty-eight male Wistar rats (2 months old) were divided into two groups, with either ligature-induced periodontal disease (LPD) or control conditions (CN). Experiments were performed in both groups 28 days after ligature placement. Plasmatic concentration of glycemia and TNF-alpha (n = 10) were analyzed by the glucose oxidase and enzyme-linked immunosorbent assay method, respectively. Insulin sensitivity (n = 7) was measured using the insulin tolerance test. Insulin signal transduction (n = 7) was measured by pp185 tyrosine phosphorylation status in insulin-sensitive tissues using the Western blotting method.Results: The LPD group showed decreased insulin sensitivity (P <0.05), although no glycemic alterations were noted (P >0.05). TNF-alpha plasmatic concentration was higher in LPD rats compared to CN rats. In addition, a decrease in the pp185 tyrosine phosphorylation status was observed after insulin stimulus in both white adipose and skeletal muscle tissues of the LPD group compared with the CN group.Conclusions: LPD is able to cause alterations to both insulin signaling and insulin sensitivity, probably because of the elevation of TNF-alpha plasmatic concentration. Thus, the present results emphasize the importance of the prevention of local inflammatory diseases, such as periodontitis, to prevent diabetes mellitus. J Periodontot 2012;83:864-870.en
dc.description.affiliationUNESP São Paulo State Univ, Dent Sch Aracatuba, Univ Estadual Paulista, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Dent Sch Aracatuba, Dept Child & Social Dent, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Inst Biomed Sci, Dept Physiol & Biophys, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Dent Sch Aracatuba, Univ Estadual Paulista, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Dent Sch Aracatuba, Dept Child & Social Dent, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Inst Biomed Sci, Dept Physiol & Biophys, BR-16015050 Aracatuba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPro-Rectory of Research of São Paulo State University
dc.description.sponsorshipIdFAPESP: 09/02976-0
dc.description.sponsorshipIdFAPESP: 09/02846-9
dc.format.extent864-870
dc.identifierhttp://dx.doi.org/10.1902/jop.2011.110349
dc.identifier.citationJournal of Periodontology. Chicago: Amer Acad Periodontology, v. 83, n. 7, p. 864-870, 2012.
dc.identifier.doi10.1902/jop.2011.110349
dc.identifier.issn0022-3492
dc.identifier.lattes4408095517346846
dc.identifier.lattes8275401688702343
dc.identifier.lattes4419158525709686
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.orcid0000-0001-5069-8812
dc.identifier.urihttp://hdl.handle.net/11449/14949
dc.identifier.wosWOS:000306535700007
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDiabetes mellitusen
dc.subjectinsulinen
dc.subjectinsulin receptor substrate proteinsen
dc.subjectinsulin resistanceen
dc.subjectperiodontitisen
dc.subjecttumor necrosis factor-alphaen
dc.titlePeriodontal Disease Decreases Insulin Sensitivity and Insulin Signalingen
dc.typeArtigo
dcterms.licensehttp://www.joponline.org/page/permissionRequests.jsp
dcterms.rightsHolderAmer Acad Periodontology
unesp.author.lattes4408095517346846[5]
unesp.author.lattes8275401688702343
unesp.author.lattes4419158525709686[6]
unesp.author.orcid0000-0003-4859-0583[5]
unesp.author.orcid0000-0001-5069-8812[6]
unesp.author.orcid0000-0003-4406-405X[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Ciências Básicas - FOA
Artigos - Odontologia Infantil e Social - FOA