Chitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases
dc.contributor.author | Balcárková, Jana | |
dc.contributor.author | Carvalho, Flavia Chiva [UNESP] | |
dc.contributor.author | Ferrari, Priscileila Colerato | |
dc.contributor.author | Cury, Beatriz Stringhetti Ferreira [UNESP] | |
dc.contributor.author | Evangelista, Raul Cesar [UNESP] | |
dc.contributor.author | Gremião, Maria Palmira Daflon [UNESP] | |
dc.contributor.author | Castro, Ana Dóris de [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2016-01-28T16:57:11Z | |
dc.date.available | 2016-01-28T16:57:11Z | |
dc.date.issued | 2012 | |
dc.description.abstract | Mucoadhesive tablets with different mixtures of chitosan and carbomer homopolymer type B were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling and erosion studies, ex vivo mucoadhesion force and in vitro drug release. The drug released mechanism was described by Korsmeyer-Peppas and Weibull models. Tablets containing increased amounts of chitosan presented higher swelling ability and the drug release was prolonged in the simulated saliva fluid. The mechanisms for the drug release from tablets were complex, including diffusion, swelling and erosion simultaneously. This kind of delivery system is suitable for formulating metronidazole mucoadhesive systems, representing a good alternative for the local treatment of periodontal diseases. | en |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rod Araraquara-Jaú Km1, CEP 14801-902, SP, Brasil | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rod Araraquara-Jaú Km1, CEP 14801-902, SP, Brasil | |
dc.format.extent | 3339-3342 | |
dc.identifier | http://connection.ebscohost.com/c/articles/84424616/chitosan-carbomer-based-tablets-containing-metronidazole-potential-treatment-periodontal-diseases | |
dc.identifier.citation | Journal of Pharmacy Research, v. 5, n. 6, p. 3339-3342, 2012. | |
dc.identifier.issn | 0974-6943 | |
dc.identifier.lattes | 5579756877261098 | |
dc.identifier.lattes | 5361569184579557 | |
dc.identifier.lattes | 9129780536724256 | |
dc.identifier.lattes | 1327549312525180 | |
dc.identifier.lattes | 0132250491238484 | |
dc.identifier.lattes | 3119063906096827 | |
dc.identifier.uri | http://hdl.handle.net/11449/133930 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Pharmacy Research | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Currículo Lattes | |
dc.subject | Mucoadhesive tablets | pt |
dc.subject | Periodontal disease | pt |
dc.subject | Metronidazole | pt |
dc.subject | Chitosan | pt |
dc.subject | Carbomer | pt |
dc.subject | Drug delivery | pt |
dc.title | Chitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases | en |
dc.type | Artigo | |
unesp.advisor.lattes | 9129780536724256 | |
unesp.author.lattes | 5579756877261098 | |
unesp.author.lattes | 5361569184579557 | |
unesp.author.lattes | 1327549312525180 | |
unesp.author.lattes | 0132250491238484 | |
unesp.author.lattes | 3119063906096827 | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |