Chitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases

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dc.contributor.authorBalcárková, Jana
dc.contributor.authorCarvalho, Flavia Chiva [UNESP]
dc.contributor.authorFerrari, Priscileila Colerato
dc.contributor.authorCury, Beatriz Stringhetti Ferreira [UNESP]
dc.contributor.authorEvangelista, Raul Cesar [UNESP]
dc.contributor.authorGremião, Maria Palmira Daflon [UNESP]
dc.contributor.authorCastro, Ana Dóris de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:57:11Z
dc.date.available2016-01-28T16:57:11Z
dc.date.issued2012
dc.description.abstractMucoadhesive tablets with different mixtures of chitosan and carbomer homopolymer type B were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling and erosion studies, ex vivo mucoadhesion force and in vitro drug release. The drug released mechanism was described by Korsmeyer-Peppas and Weibull models. Tablets containing increased amounts of chitosan presented higher swelling ability and the drug release was prolonged in the simulated saliva fluid. The mechanisms for the drug release from tablets were complex, including diffusion, swelling and erosion simultaneously. This kind of delivery system is suitable for formulating metronidazole mucoadhesive systems, representing a good alternative for the local treatment of periodontal diseases.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rod Araraquara-Jaú Km1, CEP 14801-902, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rod Araraquara-Jaú Km1, CEP 14801-902, SP, Brasil
dc.format.extent3339-3342
dc.identifierhttp://connection.ebscohost.com/c/articles/84424616/chitosan-carbomer-based-tablets-containing-metronidazole-potential-treatment-periodontal-diseases
dc.identifier.citationJournal of Pharmacy Research, v. 5, n. 6, p. 3339-3342, 2012.
dc.identifier.issn0974-6943
dc.identifier.lattes5579756877261098
dc.identifier.lattes5361569184579557
dc.identifier.lattes9129780536724256
dc.identifier.lattes1327549312525180
dc.identifier.lattes0132250491238484
dc.identifier.lattes3119063906096827
dc.identifier.urihttp://hdl.handle.net/11449/133930
dc.language.isoeng
dc.relation.ispartofJournal of Pharmacy Research
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectMucoadhesive tabletspt
dc.subjectPeriodontal diseasept
dc.subjectMetronidazolept
dc.subjectChitosanpt
dc.subjectCarbomerpt
dc.subjectDrug deliverypt
dc.titleChitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseasesen
dc.typeArtigo
unesp.advisor.lattes9129780536724256
unesp.author.lattes5579756877261098
unesp.author.lattes5361569184579557
unesp.author.lattes1327549312525180
unesp.author.lattes0132250491238484
unesp.author.lattes3119063906096827
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
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Artigos - Fármacos e Medicamentos - FCFAR